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Converting Drosophobia into Drosophila

Nature Neuroscience volume 17, pages 1430–1432 (2014)Cite this article

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Fruit flies seek water, but only when they are thirsty. And imbibing is rewarding only to water-deprived individuals. The effects of thirst on water seeking and on formation of associative memories of drinking water each are mediated by distinct sets of dopamine neurons that innervate restricted zones of the mushroom bodies in the fly brain.

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Figure 1: Anatomically distinct dopamine inputs to restricted zones of MB mediate naive and learned water seeking in Drosophila.

Marina Corral Spence/Nature Publishing Group

References

  1. Lin, S. et al. Nat. Neurosci. 17, 1536–1542 (2014).

    Article  CAS  Google Scholar 

  2. Campbell, R.A. & Turner, G.C. Curr. Biol. 20, R11–R12 (2010).

    Article  CAS  Google Scholar 

  3. Perisse, E., Burke, C., Huetteroth, W. & Waddell, S. Curr. Biol. 23, R752–R763 (2013).

    Article  CAS  Google Scholar 

  4. Montell, C. Curr. Biol. 18, R123–R126 (2008).

    Article  CAS  Google Scholar 

  5. Liu, C. et al. Nature 488, 512–516 (2012).

    Article  CAS  Google Scholar 

  6. Burke, C.J. et al. Nature 492, 433–437 (2012).

    Article  CAS  Google Scholar 

  7. Tempel, B.L., Bonini, N., Dawson, D.R. & Quinn, W.G. Proc. Natl. Acad. Sci. USA 80, 1482–1486 (1983).

    Article  CAS  Google Scholar 

  8. Krashes, M.J. & Waddell, S. J. Neurosci. 28, 3103–3113 (2008).

    Article  CAS  Google Scholar 

  9. Waddell, S. Curr. Opin. Neurobiol. 23, 324–329 (2013).

    Article  CAS  Google Scholar 

  10. Cameron, P., Hiroi, M., Ngai, J. & Scott, K. Nature 465, 91–95 (2010).

    Article  CAS  Google Scholar 

  11. Kim, Y.-C., Lee, H.-G. & Han, K.-A. J. Neurosci. 27, 7640–7647 (2007).

    Article  CAS  Google Scholar 

  12. Qin, H. et al. Curr. Biol. 22, 608–614 (2012).

    Article  CAS  Google Scholar 

  13. Tanaka, N.K., Tanimoto, H. & Ito, K. J. Comp. Neurol. 508, 711–755 (2008).

    Article  Google Scholar 

  14. Krashes, M.J. et al. Cell 139, 416–427 (2009).

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Meng-Fu Shih and Josh Dubnau are at the Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, USA.,

    Meng-Fu Maxwell Shih & Josh Dubnau

Authors
  1. Meng-Fu Maxwell Shih
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  2. Josh Dubnau
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Correspondence to Josh Dubnau.

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The authors declare no competing financial interests.

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Shih, MF., Dubnau, J. Converting Drosophobia into Drosophila. Nat Neurosci 17, 1430–1432 (2014). https://doi.org/10.1038/nn.3845

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