Abstract
We found that CNS-directed expression of interferon-γ (IFN-γ) resulted in basal ganglia calcification, reminiscent of human idiopathic basal ganglia calcification (IBGC), and nigrostriatal degeneration. Our results indicate that IFN-γ mediates age-progressive nigrostriatal degeneration in the absence of exogenous stressors. Further study of this model may provide insight into selective nigrostriatal degeneration in human IBGC and other Parkinson syndromes.
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Acknowledgements
This work was supported by the US National Institutes of Health/National Institute on Aging (T.E.G.), the Ellison Medical Foundation (T.E.G.) and American Health Assistance Foundation (P.D.).
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P.C. conducted the experiments and wrote the manuscript. C.C.-D. prepared the rAAV2/1 virus and performed quantitative real-time RT-PCR. W.-L.L. performed the electron micrography. A.B. and K.J.-W. provided technical assistance. C.J. conducted the behavioral analysis. N.R.M. and P.D. assisted with study design and interpretation. D.D. provided human tissue and conducted neuropathological analysis and interpretation. T.E.G. coordinated the research, supervised the project and assisted in manuscript preparation.
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Chakrabarty, P., Ceballos-Diaz, C., Lin, WL. et al. Interferon-γ induces progressive nigrostriatal degeneration and basal ganglia calcification. Nat Neurosci 14, 694–696 (2011). https://doi.org/10.1038/nn.2829
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DOI: https://doi.org/10.1038/nn.2829
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