Brief Communication abstract
Nature Neuroscience 12, 970 - 972 (2009)
Published online: 5 July 2009 | doi:10.1038/nn.2356
Representation of internal models of action in the autistic brain
Courtney C Haswell1, Jun Izawa1, Lauren R Dowell2, Stewart H Mostofsky2,3 & Reza Shadmehr1
Children with autism spectrum disorder (ASD) have deficits in motor control, imitation and social function. Does a dysfunction in the neural basis of representing internal models of action contribute to these problems? We measured patterns of generalization as children learned to control a novel tool and found that the autistic brain built a stronger than normal association between self-generated motor commands and proprioceptive feedback; furthermore, the greater the reliance on proprioception, the greater the child's impairments in social function and imitation.
- Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
- Kennedy Krieger Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
- Departments of Neurology and Psychiatry, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Correspondence to: Reza Shadmehr1 e-mail: shadmehr@jhu.edu
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