Article abstract
Nature Neuroscience 10, 100 - 107 (2007)
Published online: 17 December 2006 | doi:10.1038/nn1825
Coordinated memory replay in the visual cortex and hippocampus during sleep
Daoyun Ji1 & Matthew A Wilson1
Abstract
Sleep replay of awake experience in the cortex and hippocampus has been proposed to be involved in memory consolidation. However, whether temporally structured replay occurs in the cortex and whether the replay events in the two areas are related are unknown. Here we studied multicell spiking patterns in both the visual cortex and hippocampus during slow-wave sleep in rats. We found that spiking patterns not only in the cortex but also in the hippocampus were organized into frames, defined as periods of stepwise increase in neuronal population activity. The multicell firing sequences evoked by awake experience were replayed during these frames in both regions. Furthermore, replay events in the sensory cortex and hippocampus were coordinated to reflect the same experience. These results imply simultaneous reactivation of coherent memory traces in the cortex and hippocampus during sleep that may contribute to or reflect the result of the memory consolidation process.
- The Picower Institute for Learning and Memory, RIKEN-MIT Neuroscience Research Center, Department of Brain and Cognitive Sciences and Department of Biology, Massachusetts Institute of Technology, Building 46, Room 5233, 43 Vassar Street, Cambridge, Massachusetts 02139, USA.
Correspondence to: Matthew A Wilson1 e-mail: mwilson@mit.edu
Correspondence to: Daoyun Ji1 e-mail: dji@mit.edu
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