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In amyotrophic lateral sclerosis (ALS), some motor neuron types are more vulnerable to disease pathology. Here the authors show that resistant subtypes express the ER chaperone SIL1. Disease-associated loss of SIL1 impairs ER homeostasis and worsens ALS pathology, whereas its expression improves pathology and survival in an ALS mouse model.
During a single theta cycle, discrete groups of hippocampal place cells can produce a distributed series of spikes called a theta sequence. Such sequences represent the time-compressed trajectory of an animal running in its environment and usually extend ahead of the current position. Here, Wikenheiser and Redish find that the ‘look-ahead’ distance of rat theta sequences can predict the imminent choice of the animal in a value-guided decision making task.
