Comment

Cellular and organismal aging have been consistently associated with mitochondrial dysfunction and inflammation. Accumulating evidence indicates that aging-related inflammatory responses are mechanistically linked to compromised mitochondrial integrity coupled with mtDNA-driven CGAS activation, a process that is tonically inhibited by mitophagy.

Dinoflagellates are ecologically important and essential to corals and other cnidarians as phytosymbionts, but their photosystems had been underexplored. Recently, photosystem I (PSI) of dinoflagellate Symbiodinium sp. was structurally characterized using cryo-Electron Microscopy (cryo-EM). These analyses revealed a distinct organization of the PSI supercomplex, including two previously unidentified subunits, PsaT and PsaU, and shed light on interactions between light harvesting antenna proteins and the PSI core. These results have implications with respect to the evolution of dinoflagellates and their association with cnidarians.

Multidisciplinary culture-dependent and -independent techniques elucidate the unique microbial nitrogen cycle in nutrient-poor coastal Antarctica soils and reveal the contribution of novel key microbes to their nitrogen budget.

Can many-body systems be beneficial to designing quantum technologies? We address this question by examining quantum engines, where recent studies indicate potential benefits through the harnessing of many-body effects, such as divergences close to phase transitions. However, open questions remain regarding their real-world applications.

Many aspects of human health and disease are influenced by sex as a biological variable and gender as a social construct. A recent study from Nature Communications reported the landscape of outcome comparisions by sex in oncology clinical trials, highlighting the need for a more thorough reporting of sex differences.

Setting goals that are context-specific, relevant, and collectively shared is critical in adaptation. As necessary elements in target setting, imaginaries for adaptation and the language connected to them remain vague. Visuals produced through art-science collaborations can be great allies to (de)construct imaginaries and deglobalise discourses of adaptation.

Here, the authors discuss guidelines to avoid miscommunication of findings in research into sex and gender-based differences in the brain.

Sustainability of African weather and climate information can only be ensured by investing in improved scientific understanding, observational data, and model capability. These requirements must be underpinned by capacity development, knowledge management; and partnerships of co-production, communication and coordination.

Reporting in Nature Communications, Huo and colleagues provide three-dimensional structures of a bacterial immune defense system called Gabija. This work builds on recently published structural and functional studies and contributes strong evidence that protein assembly formation is essential for antiviral function.

Growth chart studies of the human cerebellum, which is increasingly recognized as pivotal for cognitive development, are rare. Gaiser and colleagues utilized population-level neuroimaging to unveil cerebellar growth charts from childhood to adolescence, offering insights into brain development.

I argue that a surface emitting laser that remains single mode irrespective of its size, a scale-invariant laser, should of necessity also waste light at the edge. This is a fundamental departure from the Schawlow-Townes two-mirror strategy that keeps light away from mirrors and edges to preserve gain and minimize loss. The strategy was implemented in the recent discovery of the Berkeley Surface Emitting Laser (BerkSEL).

Climate change and plastic pollution are interconnected global challenges. Rising temperatures and moisture alter plastic characteristics, contributing to waste, microplastic generation, and release of hazardous substances. Urgent attention is essential to comprehend and address these climate-driven effects and their consequences.

Millions of skeletal remains from South Asia were exported in red markets (the underground economy of human tissues/organs) to educational institutions globally for over a century. It is time to recognize the personhood of the people who were systematically made into anatomical objects and acknowledge the scientific racism in creating and continuing to use them.

Contact between organelles such as the mitochondria (Mito) and endoplasmic reticulum (ER) is crucial to coordinate vital cellular homeostatic processes. Here we discuss recent work showing that Mito-ER proximity is regulated by heterotypic complexes between the F-actin polymerizing protein Diaphanous-1) and the mitochondrial dynamics protein Mitofusin 2, which confers increased susceptibility to ischemia/reperfusion injury.

Selecting omic biomarkers using both their effect size and their differential status significance (i.e., selecting the “volcano-plot outer spray”) has long been equally biologically relevant and statistically troublesome. However, recent proposals are paving the way to resolving this dilemma.

The emergence of high-entropy materials has inspired the exploration of novel materials in diverse technologies. In electrochemical energy storage, high-entropy design has shown advantageous impacts on battery materials such as suppressing undesired short-range order, frustrating energy landscape, decreasing volumetric change and reducing the reliance on critical metals. This comment addresses the definition and potential improper use of the term “high entropy” in the context of battery materials design, highlights the unique properties of high-entropy materials in battery applications, and outlines the remaining challenges in the synthesis, characterization, and computational modeling of high-entropy battery materials.

Combining ocean predictions with physiological understanding yields the ability to forecast habitat multiple years into the future for a wide variety of marine organisms. However, several challenges remain before we see the regular production and use of marine habitat forecasts.

Innovative pharmacogenomic approaches (genetic variation related to medication response) are needed to reduce disease and disparities in Indigenous communities. We support community-based pharmacogenomics research, inclusive of Indigenous values and priorities, to improve the health and well-being of Indigenous peoples.

Synthetic optical materials have been recently employed as a powerful platform for the emulation of topological phenomena in wave physics. Topological phases offer exciting opportunities, not only for fundamental physics demonstrations, but also for practical technologies. Yet, their impact has so far been primarily limited to their claimed enhanced robustness. Here, we clarify the role of robustness in topological photonic systems, and we discuss how topological photonics may offer a wider range of important opportunities in science and for practical technologies, discussing emergent and exciting research directions.

The African continent demonstrated decisive leadership throughout its response to the COVID-19 pandemic, leveraging lessons learned from previous outbreaks and acting quickly to limit the impact of the SARS-CoV-2 virus. We propose a framework to build on these successes that calls for greater collaboration between African leaders, and greater inclusion of African voices in the global health ecosystem.