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  • Phenols and anilines are of extreme importance for medicinal chemistry and material science but the selective preparation of meta-substituted phenols and anilines remains challenging. Here the authors report an efficient copper-catalyzed dehydrogenation strategy to exclusively synthesize meta-carbonyl phenols and anilines from carbonyl substituted cyclohexanes.

    • Bao-Yin Zhao
    • Qiong Jia
    • Yong-Qiang Wang
    ArticleOpen Access
  • Secondary resistance to venetoclax in patients with myelodysplastic syndromes (MDS) is not completely elucidated. Here, the authors show that haematopoietic stem cells with a granulo-monocytic differentiation transcriptional state drive secondary resistance to venetoclax in MDS patients who previously failed hypomethylating agent therapy.

    • Juan Jose Rodriguez-Sevilla
    • Irene Ganan-Gomez
    • Simona Colla
    ArticleOpen Access
  • Fermi arcs show unpredictable diffraction features resulting from their long-range scattering order in aperiodic systems. Here, authors continuously twist a bi-block Weyl meta-crystal and experimentally observe the twisted Fermi arc reconstruction.

    • Hanyu Wang
    • Wei Xu
    • Biao Yang
    ArticleOpen Access
  • Mitigating the deactivation of noble metal-based catalysts caused by self-oxidation and toxic adsorption poses a considerable challenge in organic electro-oxidation. This study addresses the issue by employing a pulsed potential electrolysis approach to selectively electrocatalyze the oxidation of glycerol to glyceric acid using a Pt-based catalyst.

    • Wei Chen
    • Liang Zhang
    • Yuqin Zou
    ArticleOpen Access
  • Comparing to other biological systems, our understanding of plant extrachromosomal circular DNA (eccDNA) is limited. Here, the authors profile eccDNA from six rice tissues and investigate eccDNA characteristics, formation mechanisms, distribution, and functional implications.

    • Jundong Zhuang
    • Yaoxin Zhang
    • Tingting Lu
    ArticleOpen Access
  • Magnetic type-II Weyl semimetals host a variety of intriguing physical phenomena due to the combination of magnetic ordering and the electronic properties of the Weyl nodes. Herein, the authors explore the ultrafast spin dynamics of the magnetic Weyl semimetal, Co3Sn2S2, observing a transient enhanced magnetization as a result of laser excitation.

    • Xianyang Lu
    • Zhiyong Lin
    • Yongbing Xu
    ArticleOpen Access
  • The unification of decision-making, communication, and memory would enable the programming of intelligent biotic systems. Here, the authors achieve this goal by engineering E. coli chassis cells with an array of inducible recombinases that mediate diverse genetic programs.

    • Brian D. Huang
    • Dowan Kim
    • Corey J. Wilson
    ArticleOpen Access
  • Recent evidence suggests that senescence can negatively affect immune cell function. Here the authors show that accumulation of senescent cells in tumor-bearing mice previously exposed to irradiation or chemotherapy is associated with resistance to immune checkpoint inhibitors, associated with an exacerbated immunosuppressive profile of tumor-infiltrating myeloid cells.

    • Damien Maggiorani
    • Oanh Le
    • Christian Beauséjour
    ArticleOpen Access
  • Hair is the main skin appendage of mammals. Here, the authors show that claws of clawed frogs and hair contain homologous keratins and depend on the same transcription factor, Hoxc13, suggesting a common evolutionary origin of these skin appendages.

    • Marjolein Carron
    • Attila Placido Sachslehner
    • Leopold Eckhart
    ArticleOpen Access
  • Lipid synthesis increases during the cell cycle to ensure sufficient membrane mass. Here, authors identify a lipid checkpoint in G1 phase that prevents cells from starting the cell cycle if lipid synthesis is low, thereby preventing mitotic defects.

    • Marielle S. Köberlin
    • Yilin Fan
    • Tobias Meyer
    ArticleOpen Access
  • Ensuring high-fidelity quantum gates while increasing the number of qubits poses a great challenge. Here the authors present a scalable strategy for optimizing frequency trajectories as a form of error mitigation on a 68-qubit superconducting quantum processor, demonstrating high single- and two-qubit gate fidelities.

    • Paul V. Klimov
    • Andreas Bengtsson
    • Hartmut Neven
    ArticleOpen Access
  • This study shows that urban irrigation is capable of achieving the environmental co-benefit of heat mitigation and carbon neutrality and has the potential to counteract the climate–carbon feedback loop in the U.S. urban environment.

    • Peiyuan Li
    • Zhi-Hua Wang
    • Chenghao Wang
    ArticleOpen Access
  • The interplay between electron-phonon and spin-orbit interactions has led to the concept of a spin-orbit polaron. Here the authors show that such a regime is realized in a spin-orbit-coupled Mott insulator, leading to a new polaron quasiparticle, and study its effect on the Mott metal-insulator transition.

    • Lorenzo Celiberti
    • Dario Fiore Mosca
    • Cesare Franchini
    ArticleOpen Access
  • The liver is segregated into spatially organized areas that serve distinct functions, though how these zones are patterned remains unclear. Here they show that mTORC1 controls spatial segregation of liver metabolic functions via modulation of Wnt signaling, and find that impaired zonation is also observed in pigs given total parenteral nutrition.

    • Ana Belén Plata-Gómez
    • Lucía de Prado-Rivas
    • Alejo Efeyan
    ArticleOpen Access