Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain
the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in
Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles
and JavaScript.
The potential of organic phototransistors to surpass silicon-based devices is limited by the low carrier mobility of organic photoresponsive materials. Here, Ji et al. report high performance organic phototransistors featuring vacuum-deposited small-molecule films with band-like charge transport.
Antarctic sea ice extent declined dramatically in austral spring 2016. This study shows the decline was initially driven by tropical convection resulting in a wave-3 circulation pattern, followed by weakened circumpolar surface westerlies initialised in the polar stratospheric vortex.
Climate change will affect both the demand for electrical power and the generating capabilities of hydropower plants. Here the authors investigated the combined impact of these effects in the US Pacific Northwest by considering the dynamics of the regional power grid, where they reveal a profound impact of climate change on power shortfall risk by the year 2035.
Previous research on visual memory often relies on image recognition as a test, and the exact nature of memory when freely recalling information is not clear. Here, Bainbridge and colleagues develop a drawing-based memory recall task, and show detailed-rich, quantifiable information diagnostic of previously encountered visual scenes.
Parasitic nematodes causing onchocerciasis and lymphatic filariasis rely on a bacterial endosymbiont, Wolbachia, which is a validated therapeutic target. Here, Clare et al. perform a high-throughput screen of 1.3 million compounds and identify 5 chemotypes with faster kill rates than existing anti-Wolbachia drugs.
Due to various structural and sequence complexities, the human Y chromosome is challenging to sequence and characterize. Here, the authors develop a strategy to sequence native, unamplified flow sorted Y chromosomes with a nanopore sequencing platform, and report the first assembly of a human Y chromosome of African origin.
The role of innate T cell subsets in the pathogenesis of spondyloarthritis (SpA) is not well understood. Here, the authors examine the role of invariant natural killer T (iNKT) and γδ-T cells in SpA and show that disease-derived iNKT and γδ-T cells have unique and Th17-skewed phenotype and gene expression profiles within inflamed joints.
Genetic variants might exert their functional effects via influencing molecular interaction. Here, the authors present a resource featuring almost 28,000 annotations describing the effect of small sequence changes on physical protein interactions, curated by IMEx Consortium curators.
The influence of 'fake news’, spread via social media, has been much discussed in the context of the 2016 US presidential election. Here, the authors use data on 30 million tweets to show how content classified as fake news diffused on Twitter before the election.
Ultrathin nanopore membranes have the potential for detecting topological variation in DNA. Here the authors use barcoded DNA to characterise the translocation profiles of DNA with single strand gaps.
The PI3K/Akt/mTOR pathway has been previously implicated in fibrosis and a pan-PI3K/mTOR inhibitor is currently under clinical evaluation for the treatment of IPF. Here the authors show that the mTORC1/4E-BP1 axis is critical for TGF-β1-induced fibrogenesis in in vitro and ex vivo models and that canonical PI3K/Akt signalling is dispensable.
