Review Articles

Smartphone-based mobile health platforms have drawn increasing attention from researchers developing point-of-care testing devices. Here the authors summarize recent progress and future directions of approaches combining microfluidics and artificial intelligence.

Zooplankton are a critical link to higher trophic levels and play an important role in global biogeochemical cycles. This Review examines key responses of zooplankton to ocean warming, highlights key knowledge and geographic gaps that need to be addressed, and discusses how better use of observations and long-term zooplankton monitoring programmes can help fill these gaps.

Here the authors summarize current knowledge of the regulation of protein stability by various post-translational modifications (PTMs) including methylation and phosphorylation. PTM-regulated degrons act as signals for protein degradation or stabilization.

CRISPR-Cas tools have shown exceptional promise in genome engineering over the past decade. Here the authors review the development of CRISPR-Cas9/Cas12/Cas13 nucleases, DNA base editors, prime editors, and RNA base editors, as well as their editing precision, off-target effects, and clinical considerations.

While the contribution of sharp wave ripples in memory consolidation and decision-making is established in rodent models, our understanding of their role in human memory is incomplete. Here, the authors discuss common methodological challenges in detecting, analyzing, and reporting sharp wave ripples, then they suggest practical solutions to distinguish them from other high-frequency events

Microbots have attracted attention due to an ability to reach places and perform tasks which are not possible with conventional techniques in a wide range of applications. Here, the authors review the recent work in the field on the fabrication, application and actuation of 3D printed microbots offering a view of the direction of future microbot research.

The impact of fungal infections on human health has been exacerbated by the rise of antifungal drug resistance. In this Review, the authors outline the problem of antifungal resistance and suggest how this growing threat might be mitigated.

In this review, the authors look at how recent progress in single-cell transcriptomics complement and enrich the classical, largely morphological, portraits of fibroblasts. The detailed molecular information now available provides new insights into fibroblast identity, heterogeneity and function.

Deep learning has enabled advances in understanding biology. In this review, the authors outline advances, and limitations of deep learning in five broad areas and the future challenges for the biosciences.

In this Review, the authors discuss recent technological and neuroscientific advances in human body augmentation. They construct a movement augmentation taxonomy, discuss how it is achieved, and propose a vision for the field.

Large scale sustainable energy storage by water splitting benefits from performing the oxygen evolution reaction under a variety of conditions. Here, the authors discuss self-healing catalysis as a new tool in the design of stable and functionally active catalysts in acidic to basic solutions, and a variety of water sources

Transition-metal-catalyzed C–H arylations are an effective tool for the construction of biaryl motifs in an efficient and selective manner. Here the authors provide an overview of the state-of-the-art of the field and perspectives on emerging directions toward increased sustainability.

Synthetic DNA is the basis for promising technologies in data storage, barcoding, computing 62 and sercurity. In this review, the authors provide an overview of the field and its future.

New observations of volcanic and magmatic activity in Africa are changing our views of continental rifting and raising awareness of the associated hazards. However, despite a shift from crisis response to reducing disaster risks, limited capacity means mitigating geohazards remains challenging.

Cellular microbiology is a field that combines the study of infection and cell biology. In this review, we highlight emerging technologies and infection models that recently transformed our understanding of the infected cell and may inspire future medicine.

The high platinum loadings at the cathodes of proton exchange membrane fuel cells significantly contribute to the cost of these clean energy conversion devices. Here, the authors critically review and discuss recent developments on low- and non-platinum-based cathode catalysts and catalyst layers.

Large-scale manufacturing of high-energy Li-ion cells is of paramount importance for developing efficient rechargeable battery systems. Here, the authors report in-depth discussions and evaluations on the use of silicon-containing anodes together with insertion-based cathodes.

Seed banks are generated when individuals enter a dormant state, a phenomenon that has evolved among diverse taxa, but that is also found in stem cells, brains, and tumors. Here, Lennon et al. synthesize the fundamentals of seed-bank theory and the emergence of complex patterns and dynamics in mathematics and the life sciences.

Mosquito-borne diseases pose significant global health burdens. In this review, the authors explore Wolbachia and genome engineering approaches to mosquito-borne disease population control.

The application space for optical fibers is growing, enabled by fibers built using special materials and processes. In this Review, the authors discuss the materials science behind producing crystalline core fibers for diverse applications and progress in the field.