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New study shows that up to 50% of properties flooded after hurricane Harvey flooded because of climate change, with low-income and Latina/x/o neighborhoods experiencing higher climate change-attributed impacts.
Warm-season O3 pollution has been increasingly frequent worldwide in the past few years, exposing a threat to human health as well as the natural environment. Here, the authors showcase a stable MOF which can not only effectively capture various airborne VOCs, but decompose trace O3 in ambient air.
A recent synthesis study found 54% of the high-latitude peatlands have been drying and 32% have been wetting over the past centuries, illustrating their complex ecohydrological dynamics and highly uncertain responses to a warming climate.
Ternary chalcogenides are gaining interest as nontoxic, stable solar absorbers. Here, the authors investigate NaBiS2, finding cation disorder to be a critical parameter that enables its high absorption strength and unusual charge-carrier kinetics.
Splicing QTL (sQTL), genetic variants regulating alternative splicing, can be biologically important, but complex to detect and interpret. Here, the authors identify sQTL by focusing on protein coding sequences, as an alternative to junction-based approaches.
The adenomatous polyposis coli (APC)–Asef protein interaction is essential for colorectal cancer metastasis. Here, the authors present the rational design of a sensitivity-enhanced tracer for fluorescence polarization assays, enabling them to discover more efficient APC–Asef interaction inhibitors.
A new study characterizes adaptation in mitigation pathways, and shows that climate adaptation can lead to higher energy demand, power system costs and carbon prices, with mitigation’s benefits compensating decarbonization costs.
Globally it is recognised that Indigenous populations should be able to access the benefits of genomics and precision medicine. Here, authors show that there are disparities in access to clinical genetic health services for Aboriginal and/or Torres Strait Islander people in Australia.
Arctic warming thaws permafrost, leading to enhanced soil mercury transport to the Arctic Ocean. Mercury isotope signatures in arctic rivers, ocean and atmosphere suggest that permafrost mercury is buried in marine sediment and not emitted to the global atmosphere
The mechanisms underpinning the variability in methylphenidate’s effects on cognition remain unclear. Here, the authors show that such effects reflect changes in striatal dopamine-related output gating of task-relevant cortical signals, and that these changes depend on baseline dopamine synthesis capacity.
Most of the intensive human activities usually occur in lowlands. Here the authors report that human activity expansions also were widely distributed in Asian highlands in the 21st century and held dual effects, which provides new insights for regional human activity expansions.
Unwanted RNA transcripts are targeted for degradation by nuclear complexes such as MTREC/PAXT. Here, the authors structurally and functionally characterized three interfaces of the scaffold protein Red1, providing mechanistic insights into conserved features of MTREC/PAXT architecture.
The SARS-CoV-2 Omicron variant spreads rapidly. Here the authors show that Omicron S preferentially adopts the one-RBD-up conformation, which leads to a non-RBM-binding monoclonal antibody escape. Mutagenesis reveals that S371L, S373P and S375F substitutions enhance the conformational stability.
Transistors with inorganic semiconductors have superior performance than organics. However, they are brittle and thus unfavorable for building deformable electronics. Here, authors directly embed such inorganic thin film transistors into serpentine strings to realize highly stretchable and miniaturized electronic circuits.
Controlled molecular separation by membranes requires 2D materials with precise structures to achieve the desired selectivity. Here authors demonstrate precise selectivity tuning in carbon membranes using electron irradiation.
Osmotic power source based on 2D nanofluidic graphene oxide could overcome humidity and temperature limitations due to high areal power density purely from ion gradient. Here, authors couple it with triboelectric nanogenerator, and demonstrate a self-chargeable conformable tribo-iontronic device.
Ziegler-type polyolefin catalysts have proven to be hard to characterize. Here the authors present a model system consisting of patterned LaOCl spherical caps, simulating bulk particles while facilitating the use of micro(-spectro)scopic characterization techniques specifically aimed at surfaces.
Perceptual segmentation, grouping distinct parts of the input for further processing, is a hard problem for sensory systems. Here, the authors report a link between spiking activity in primate visual cortical area MT and subjective segmentation.
Detection of mutational signatures in cell-free DNA (cfDNA) is challenging due to low sequence coverage and low mutant allele fractions. Here, the authors identify mutational signatures in plasma whole genome sequencing of cancer patients and use machine learning to distinguish them from healthy individuals.
Differentiation and activation of T cells are normally modulated by non-covalent interactions between T cell receptor (TCR) and antigenic peptides. Here the authors use step-wise mutations, biochemical characterization and structural insights to describe the contributions of natural covalent bonds between TCR and antigenic peptides during these processes.