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Careful measurements of the zero-field quantum anomalous Hall effect find a less-precisely-quantized Hall conductivity than the integer quantum Hall effect. Here, the authors theoretically study the effects of nonlinear corrections to the Hall conductivity in both topological and trivial magnetic insulators.
Charge carrier transport in colloidal quantum dot assemblies is slow due to hopping transport nature. Here, the authors report the demonstration of gate-tuned metallic state in epitaxially-connected quantum dot superlattices by minimizing disorders.
cGAS/STING activation is linked to the induction of anti-tumor immune responses. Here the authors report a role for the deubiquitinating enzyme TRABID in regulating mitotic cell division and suppressing anti-tumor immunity, suggesting that TRABID inhibition induces micronuclei and activates cGAS/STING pathway.
Binding antibody levels correlate with protection against infection with the ancestral SARS-CoV-2 strain, but it is not clear whether this relationship extends to the Omicron variant. Here, the authors characterise antibody dynamics and their relationship with Omicron infection in a longitudinal cohort from Geneva, Switzerland.
Understanding the mode of small-molecule binding to amyloid filaments is critical for diagnosing and treating neurodegeneration. The authors use cryo-EM to reveal a stacked binding motif which may hasten design of diagnostics and therapeutics.
Superconducting interfaces involving KTaO3 have recently attracted attention due to their relatively high transition temperature. Here, the authors study amorphous-YAlO3/KTaO3 interfaces and find two-fold symmetry in the superconducting regime, possibly due to a mixed-parity superconducting state.
Fingering patterns form spontaneously when a non-wetting viscous liquid displaces a dry granular mixture in a confined flow cell. The authors show how these patterns are controlled by the balance between viscous, capillary, and frictional forces.
Most intestinal organoid models do not accurately model the interactions between epithelial and stromal cells. Here they establish a colon assembloid system with epithelial and stromal cells and demonstrate that BMP signals from differentiating epithelial cells promote mesenchymal niche organization.
Methylation is a common modification that affects protein function but, compared to other modifications, our knowledge is limited. Here, the authors use a method based on thermal stability to study how protein methylation regulates processes such as mRNA binding proteins and chromosome compaction.
Here the authors develop a neonatal mouse model for SARS-CoV-2 transmission, characterize differences in viral replication and shedding of variants of concerns, and show that deletion of ORF8 shifts viral replication to the lower respiratory tract and delays transmission.
Retrosynthesis prediction is a fundamental problem in organic synthesis. Here, inspired by simplified arrow-pushing reaction mechanisms, the authors develop a graph-to-edits framework, Graph2Edits, based on graph neural network for retrosynthesis prediction.
Rubisco is responsible for sequestering virtually all of the carbon dioxide in the global carbon cycle. Here, the authors demonstrate that two conserved phosphatases degrade Rubisco misfire products that inhibit photosynthesis in plants.
Although accumulating evidence indicates that epithelial cell cycle G2/M arrest is involved in kidney fibrosis, the underlying mechanism remains unclear. Here, the authors show that HDAC9 is upregulated in the fibrotic kidney and promotes epithelial cell cycle arrest in G2/M by regulating STAT1.
It is historically assumed point defects in metals coalesce directly into larger dislocation loops. Here the authors revise the fundamental mechanism, reveal the formation of A15 nano-phase clusters in fcc metals prior to dislocation loops, and highlight the major implications of this discovery.
Here, the authors propose a strategy to create amorphous oxides by bridging fluorite HfO2 and perovskite hafnate, which exhibit ultrahigh breakdown strength of 12 MV/cm and energy density of 155 J/cm3.
Detecting cell type-specific genetic effects on gene expression is challenging in bulk RNA-seq data. Here, the authors develop a method to increase power which incorporates allele-specific expression and does not transform the gene expression data.
Here, the authors combine isolation and sequencing of bacteria from both mothers and infants and to show that several microbial strains are commonly transferred, including from the genus Bifidobacterium, with factors that influencing transfer including delivery mode and exposure to antibiotics in labour.
Tungsten-based alloys with ultrahigh strength and ductility are in high demand for a wide range of applications, potentially for fusion reactors. Here the authors develop a tungsten refractory high-entropy alloy with high strength (~2.15 GPa) and sufficient ductility (~15%).
Surface Pourbaix diagrams are critical to understanding the stability of nanomaterials. Here, the authors develop a bond-type embedded crystal graph convolutional neural network model and construct reliable Pourbaix diagrams for real-scale nanoparticles.
Optimisation of production of recombinant proteins is pharmaceutically important. Here, the authors identify a state of secretion burnout for cells and report a strategy in which induction is dynamically adjusted based on the current cell stress to avoid the appearance of burnt-out cells.