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The quest for high-energy electrochemical energy storage systems has driven researchers to look toward highly concentrated electrolytes. Here, the author discusses the recent progress and future perspectives of such electrolytes and their ability to improve the performances of lithium-based batteries.
Diabetic kidney disease leads to changes in glucose metabolism and inflammation. Here the authors use multimodal single cell sequencing to show that this disease leads to reduced accessibility of glucocorticoid receptor binding sites in the proximal tubule and increased gluconeogenesis.
Here, using whole-metagenome shotgun sequencing data from patients with COVID-19 and controls, the authors reconstruct 11,584 microbial metagenome-assembled genomes (MAGs) including 5,403 non-redundant MAGs, revealing microbiota and metabolic pathways associations with SARS-CoV-2 infection at strain-level resolution.
Efficient engineering of enzymes for expanded substrate scope is currently challenging. Here, the authors develop simple principles of how to design and interpret Substrate Multiplexed Screening assays to guide protein engineering to enable activity improvements with simultaneously with multiple substrates.
The genetic bases of yak adaptations to extreme conditions remains elusive. This study compares yak and cattle at a genomic and transcriptomic level, revealing a new type of endothelial cell and candidate genes related with elastic fiber formation in yak lungs that might contribute to high altitude adaptation.
In vivo surface-enhanced Raman scattering (SERS) imaging allows non-invasive visualization of tumours for biomedical applications. Here, the authors report porous cubic AuAg alloy nanoshells exhibiting plasmonic properties and porosity-dependant SERS in the second window of the near-infrared for in vivo tumour detection.
While obtaining H2 from water splitting offers a promising strategy for renewable fuel production, current technologies rely on liquid freshwater. Here, authors use a hygroscopic electrolyte to achieve electrocatalytic water vapor splitting driven by renewable resources without liquid water.
The develop of organic functional materials requires the exploration of the pressure dependent emissive mechanisms of molecular structures, conformations and stacking modes. Here, Tong et al propose a strategy for monitoring the pressure-induced fluorescence under multiple excitation channels.
Using one carbon compounds as feedstock is a promising approach in abating climate change. Here, the authors report the conversion of E. coli into a synthetic methylotroph that assimilates methanol via the ribulose monophosphate cycle and a set of distinctive mutations.
Efficient mobilization and expression of biosynthetic gene clusters (BGCs) into heterologous hosts is needed for microbial natural products discovery. Here, the authors improve the CONKAT-seq strategy by simultaneously capturing the BCGs into a single large insert library and demonstrate its ability to discover natural products with new structures and potent antibacterial activity.
Elastic anisotropy of liquid crystals elastomers is typically measured at low frequencies for the applications such as soft robotics, actuators, and origami. Here the authors study the elastic anisotropy of LCE using Brillouin light spectroscopy at gigahertz frequencies such as radio frequencies or 5 G cellular networks.
Here, Nishijima et al. perform a large-scale analysis of the human gut virome in the Japanese 4D cohort of 4198 deeply phenotyped individuals, revealing thousands of bacteriophage genomes, virus-bacteria interactions, and describing associations with various host and environmental factors.
The authors introduce differentially enhanced compressed ultrafast photography, a phase imaging platform that combines high speed and sensitivity. They visualise propagation of passive current flows along myelinated axons, and electromagnetic pulses in lithium niobate.
Despite archaeobotanical evidence for domesticated cereals, organic residue evidence is scarce. Here, the authors identify cereal-specific markers in pottery from Scottish ‘crannogs’, revealing the presence of cereals in Neolithic pottery which might have been mixed with dairy products as a milk-based gruel.
Van der Waals crystals allow for magnetism down to the monolayer limit, however, this magnetism, and frequently the material itself, is fragile. Ferrites, conversely, have robust material stability and magnetic order, but are three dimensional. Here the authors succeed in creating a single unit cell thickness of Cobalt Ferrite via chemical vapour deposition, with hard magnetic properties, and curie temperature exceeding room temperature.
The singlet fission mechanism is still not relatively well understood, except for polyacenes. Here, the authors demonstrate that in diketopyrrolopyrrole supramolecular assemblies, both singlet fission and intersystem crossing can simultaneously happen.
Protein kinase-mediated phosphorylation plays a critical role in many biological processes. Here the authors develop a trans-omics-based algorithm called Central Kinase Inference to integrate quantitative transcriptomic and phosphoproteomic data, finding that PIM1 promotes hepatic conversion by suppressing reprogramming-induced ferroptosis and cell cycle arrest.
SIVmac239 infection of macaques is a favored model of human HIV infection, but antibody-mediated protection for SIVmac239 is insufficiently understood. Here, Zhao and Berndsen et al isolated nAbs and confirmed protection against SIVmac239 infection in passive transfer studies in macaques. The nAb was used to provide the first high-resolution structure of a rhesus SIV trimer by CryoEM. Analysis of the glycosylation pattern of this SIV trimer suggests a denser glycan shield on Env for rhesus SIV compared to chimpanzee SIV or HIV-1, which partially explains the poor nAb response of rhesus macaques to SIVmac239 infection.