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An intracellular antenna that can truly enable probing, modulation or augmentation of biological cells remains an unmet challenge. Here, the authors present the Cell Rover, a magnetostrictive antenna that operates wirelessly inside a living cell and is compatible with 3D biological systems.
Multiple alternative splicing events in CD19 mRNA have been associated with resistance/relapse to CD19 CAR-T therapy in patients with B cell malignancies. Here, by combining patient data and a high-throughput mutagenesis screen, the authors identify single point mutations and RNA-binding proteins that can control CD19 splicing and be associated with CD19 CAR-T therapy resistance.
Ganglion cells classically respond to either light increase (ON) or decrease (OFF). Here, the authors show that during natural scene stimulation, a single ganglion cell can switch between ON and OFF depending on the visual context.
A major challenge for the effective use of Ti-based MXenes in applications with harsh environmental conditions is their poor resistance to oxidation. Here, authors report an air-stable Ti3C2Tx composite with extracted bentonite able to endure high-temperature annealing in air by an oxygen adsorption competition mechanism.
Horizontal gene transfer in bacteria can occur through mechanisms such as conjugation, transduction and transformation, which facilitate the passage of DNA across the cell wall. Here, Kapteijn et al. show that cell wall-deficient bacteria can take up DNA and other extracellular materials via an endocytosis-like process.
In this review, the authors define protein condensation diseases as conditions caused by aberrant liquid-like or solid-like states of proteins, and describe opportunities for therapeutic interventions to restore the normal phase behaviour of proteins. The review accompanies the related collection of articles published in Nature Communications focusing on possible therapeutic approaches involving liquid-liquid phase separation.
Ambipolar organic electrochemical transistors simplify bioelectronics circuitry but are challenging due to complicated material design and synthesis. Here, the authors demonstrate that p- and n-type blends offer a simple and tuneable approach for the fabrication of ambipolar devices and circuits.
Colloidal liquid crystals account for various applications due to the combination of characteristics relevant for liquid crystals and colloids. The authors elaborate the impact of concave geometry on the properties of colloidal liquid crystals for development of functional materials.
Side-on configuration of O2 on the catalysts conventionally leads to reduction of O2 to water. Here, the authors propose a nitrogen doping strategy with Pauling-type adsorption of O2 for selective electrocatalytic singlet oxygen production.
The microtubule plus-end tracking protein Tip1 regulates microtubule dynamics and polar growth in fission yeast. Here the authors link the ubiquitination of Tip1 by ubiquitin ligase Dma1 to polarized growth inhibition upon DNA replication stress.
Spontaneous monodispersion of active species and their stabilization in reductive atmospheres remain a challenge in catalytic syngas chemistry. Here the authors demonstrate that syngas-to-aromatic conversion can be significantly accelerated by the spontaneously monodispersed Fe in ZnCr2O4 spinel.
Managing herbicide resistance problem needs the identification of new herbicidal modes of action. Here, the authors solve the crystal structures of Arabidopsis HMGR and show HMGR as a potential new herbicide target by identifying plant-specific HMGR inhibitors and engineering tolerant trait in Arabidopsis.
Observation of a Bloch-Siegert shift has remained elusive. Here, Wu et al, reports spin-selective Bloch-Siegert shift in lead halide perovskite quantum dots, and highlights the importance of many-body interactions in correctly modeling the shift.
Here the authors show the identity of CD4 + CD8 + double-positive (DP) thymocytes changes upon loss of chromatin organizer Satb1, which controls the expression of cell identity genes by regulating super-enhancers via 3D genome architecture.
Scaling up anisotropic freeze-casting processes can be challenging due to the temperature gradient farther from the cold source. Here, authors report an additive freeze-casting technique able to produce large-scale aerogel panels and demonstrate it towards practical passive cooling applications.
This study finds that glaciers have existed in the Transantarctic Mountains for the past 60 million years, and that warm-based mountain glaciers were present in Antarctica long before ice sheets came to dominate the continent.
Strategies for the catalytic asymmetric synthesis of trifluoromethylated compounds remain scarce. Here, the authors report the nickel-catalyzed enantioselective dicarbofunctionalization of 3,3,3-trifluoropropene.
The authors show in an animal model and in a study in patients with dementia with Lewy bodies (DLB) that the drug neflamapimod has potential to treat diseases, such as DLB, associated with loss of neurons that produce the neurotransmitter acetylcholine.