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Water electrolysis typically requires a large voltage input and produces H2 only at the cathode. Here the authors present a strategy of coupling formaldehyde oxidation with water reduction and report H2 production at both anode and cathode with small voltage inputs.
The CaV2.3 channel is involved in synaptic plasticity and neurological disorders. Here, authors resolve the human CaV2.3 structure to explore functional heterogeneity of VSDs and elucidated the closed- and open-state inactivation mechanisms of the channel.
Here, using a mouse model, the authors report a previously undescribed role for medium-chain acyl-CoA dehydrogenase in host metabolism of gut microbiota metabolites, and show that circulating compounds, including the abundant organic acid hippurate, depend on host-microbe co-metabolism of phenylalanine by Clostridium sporogenes.
‘Manufacturing CAR-T cells is a streamlined and highly regulated procedure involving T-cell-expansion and activation on a standardised platform. Here, the authors show that a personalized approach, taking the phenotypic attributes of individual patients’ T cells into account, leads to more efficient CAR-T cell manufacturing and better CAR-T cell functionality.
To elucidate the relationship between sociality and longevity, the authors perform phylogenetic and transcriptomic comparative analysis of mammals. They find that group-living species lived longer than solitary species and identify 31 genes, hormones, and immunity-related pathways involved in this connection.
Hardware-based neural networks can provide a significant breakthrough in artificial intelligence. Here, the authors demonstrate an integrated 3-dimensional ferroelectric array with a layer-by-layer computation for area-efficient neural networks.
This study establishes that the magnitude of observed physical changes in coral reef islands over the period of recent global warming is not unprecedented, and islands have continually adjusted to environmental change over the past millennia.
How memories are modified by new experiences remain elusive. Here, authors show that specific or generalized modification of memories depends on whether synaptic changes associated with previous memories are segregated or co-exist in dendritic branches.
Algal blooms are hotspots of marine primary production that play central roles in microbial ecology and global elemental cycling. Here, the authors show how bloom termination by viral infection can shift the balance between eukaryotic and prokaryotic recyclers of phytoplankton biomass.
Tuning electrocatalytic reduction of carbon monoxide to achieve valuable ethanol product with high performance is interesting yet challenging. Here, the authors design a hydrophobic Cu/Cu2O sheet catalyst showing a FE of 68.8% and partial current density of 111 mA cm−2 for CO reduction to ethanol.
A series of materials containing Mo-S clusters confined in zeolitic cages of ZSM-5 are reported and shown to be efficient for CO2 or CO hydrogenation with >98% selectivity to methanol, stable over 1000 h, or C2 and C3 hydrocarbons, stable over 100 h.
Metagenomic Hi-C enables genome retrieval in microbial samples. Here, the authors develop an integrative method to recover complete viral genomes and detect virus-host pairs using metagenomic Hi-C data.
Quantum transport of fractional quasiparticles can drastically differ from conventional charge transport. Here the authors demonstrate Andreev-like reflection of a fractional quasiparticle incident on a barrier in the fractional quantum Hall regime.
The proteogenomic landscape of diffuse gliomas remains to be explored. Here, the authors perform proteogenomic characterisation of diffuse gliomas, investigate the functional role of genomic alterations and suggest three proteomic subgroups.
Fibroblast heterogeneity is a prominent but poorly understood feature of solid tumours. Here three major fibroblast subpopulations in non-small cell lung cancer are identified and characterised through single cell RNA-sequencing, multiplexed immunohistochemistry and digital cytometry.
Sensing small biomolecules in biofluids using host-guest chemosensors remains challenging, in part due to the impact of interfering components. Here, the authors develop a dual-macrocyclic rotaxane for tryptophan detection which can function in biofluids such as human serum and urine.
Follicle stimulating hormone (FSH) is a glycoprotein hormone the functions of which are mediated by a G protein-coupled receptor, FSHR. Here, Duan et al. report cryo-EM structures of FSHR in active and inactive states, suggesting the molecular basis of FSH and small allosteric agonist-mediated FSHR activation.
Spatial transcriptomics relies on RNA quality, which is variable and dependent on sample handling, storage, and/or intrinsic factors. Here, authors present a genome-wide spatial gene expression profiling method called RNA Rescue Spatial Transcriptomics (RRST), designed for the analysis of moderate to low quality fresh frozen tissue samples and demonstrate its robustness on 7 different tissue types.