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The RNA binding protein RBM5 regulates alternative splicing of genes implicated in cancer. Here the authors show structural mechanisms how multiple RNA binding domains of RBM5 cooperate to recognize specific target RNA sequences.
The mechanisms for oxygen evolution reaction on layered double hydroxides remain controversial. Here, the authors use a computational methodology by combining grand-canonical methods and microkinetic modeling to unravel the potential-dependent transitions mechanisms for electrochemical reactions.
Birds can adapt to temperature gradients by changing body size (Bergmann’s rule) or bill size (Allen’s rule), but many groups don’t conform to these patterns. Here the authors show that most bird families show subtle and complementary changes in bill and body size, while also being constrained by feeding ecology.
Hospitalisation with COVID-19 is associated with an increased risk of neurological sequelae. Here in a nationwide Danish register study, the authors show that positive SARS-CoV-2 PCR tests and hospitalisations with COVID-19 are associated with increased risk of neurological sequelae, but with comparable risks as after other infections of similar severity.
Concurrent chemoradiation and durvalumab is standard of care for stage III non-small cell lung cancer, however, efficacy is variable. Here, the authors show PD-L1 tumor proportion score expression and increased tumor mutational burden are predictive of response and that early-onset pneumonitis leading to durvalumab discontinuation is associated with poor survival.
DNA-programmed colloidal assembly of macroscopic crystals for photonic applications remains elusive. Here, the authors use insights from studies of nucleation and seeded growth to develop a two-step method for assembling macroscopic photonic crystals.
PfCRT is a chloroquine resistance transporter from malaria parasite Plasmodium falciparum, which is sensitive to acidic pH. Here, the authors show that residue E207 is critical for pH sensing by PfCRT, using alanine-scanning mutagenesis, MD simulations and drug uptake assays.
mRNA nanomedicine-based gene therapy may offer opportunities for cancer treatment. Here the authors show that mRNA lipid nanoparticles encoding the N-terminal domain of gasdermin B trigger pyroptosis and promote anti-tumor immune responses in preclinical cancer models.
It is critical to understand what drives the progression of oesophageal adenocarcinoma (OAC) from a pre-cancerous state. Here, the authors use whole-genome sequencing to characterise the mutational processes and drivers of OAC progression from Barrett’s Oesophagus, as well as their prognostic associations.
The bulk photovoltaic effect (BPVE) is a nonlinear optical effect offering a promising approach to overcome the limitations of conventional photovoltaics. Here, the authors report the observation of BPVE-induced photocurrents at the edges of 2D semiconductors embedded in various van der Waals heterostructures.
Amyloid precursor protein has been identified as an inhibitor of HIV-1 replication. Here, Gu et al further characterise the details and impact of this interaction on HIV replication in myeloid cells that contribute to neurological disease.
The role of PHD finger protein 8 (PHF8) in anti-tumour immunity remains to be investigated. Here, the authors suggest PHF8 as an epigenetic checkpoint and show that targeting PHF8 induces a viral mimicry response enhancing anti-tumour immunity in colorectal cancer.
Sustainable recycling of waste plastics is of highly strategic significance. Here, the authors report a photothermal recycling system for transforming polyolefin plastics into high-selectivity liquid fuels through the synergistic utilization of ultraviolet, visible, and near-infrared irradiation.
Rare quantum tunneling two-level systems are known to govern the glass physics at low temperatures, but it remains challenging to detect them in simulations. Ciarella et al. show a machine learning approach to efficiently identify the structural defects, allowing to predict the quantum splitting.
The authors report the location-selective immobilisation of single Pt atoms on the surface or within the interior of CdSe nanoplatelets using coordination chemistry and show location-dependent photocatalytic reactivity.
Developing porous systems with high molecular recognition performance can be challenging. Here the authors present a corrugated channel system that cooperatively responds to only CO2 molecules over nine other similar gas molecules.
Ensitrelvir is an oral antiviral agent that targets SARS-CoV-2 and is clinically useful against infection with omicron variants. The authors characterized mutant viruses with reduced sensitivity to ensitrelvir in vitro and in vivo.
Cooperative interactions might be important in spatially structured microbial habitats. Here, the authors show that cooperative interactions between planktonic and biofilm-forming bacteria drive spatial segregation, and thereby enable species’ coexistence, in a microfluidic chip environment.
Divalent cation block is observed in various tetrameric ion channels. Here, authors use X-ray crystallography, electrophysiology and molecular dynamics simulations to reveal the mechanism of the divalent cation block on a prokaryotic sodium channel.