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  • Chemical manipulation of fullerenes has allowed the production of heptagon-containing fullerenes, but they have not been synthesised using bottom-up approaches. Here, a heptagon-containing fullerene[68] is obtained as C68Cl6from a carbon arc plasma.

    • Yuan-Zhi Tan
    • Rui-Ting Chen
    • Lan-Sun Zheng
    ArticleOpen Access
  • Magnesium is an ideal rechargeable battery anode material, but coupling it with a low-cost sulphur cathode, requires a non-nucleophilic electrolyte. Kimet al. prepare a non-nucleophilic electrolyte from hexamethyldisilazide magnesium chloride and aluminium trichloride, and show its compatibility with a sulphur cathode.

    • Hee Soo Kim
    • Timothy S. Arthur
    • John Muldoon
    ArticleOpen Access
  • Bird wings resemble the digits on the hands of dinosaurs, but which digit positions gave rise to those seen in modern birds is still unclear. In this work, long-term fate maps of the chick wing polarizing region are presented, supporting fossil data that birds descended from theropods that had digits 1, 2 and 3.

    • Matthew Towers
    • Jason Signolet
    • Cheryll Tickle
    Article
  • Direct negative feedback decreases fluctuations in homoeostatic control, but intracellular regulatory systems are indirect. Here, an analytical expression is derived to show that indirect feedback in transcription and translation leads to more fluctuations for intermediate delays but not for long delays.

    • Andreas Grönlund
    • Per Lötstedt
    • Johan Elf
    Article
  • Cytoplasmic flows—the movement of cytoplasmic material—can be detected following the fertilization of an egg by a sperm in many species. In this study, rhythmic cytoplasmic flows are shown to be induced in mice by calcium-induced cytoskeleton contractions which could be used to predict the successful outcome of fertilization.

    • Anna Ajduk
    • Tagbo Ilozue
    • Magdalena Zernicka-Goetz
    ArticleOpen Access
  • Single atoms can be detected using optical resonators that extend the lifetime of the photon. Here, the authors demonstrate fast, high-fidelity detection of very low atom densities using a microfabricated optical cavity to couple the detection light with the atoms.

    • J. Goldwin
    • M. Trupke
    • E.A. Hinds
    ArticleOpen Access
  • The chronic disease schistosomiasis is caused by the blood flukeSchistosoma mansoni. By studying DNA modifications throughout the lifecycle of the pathogen, the authors identify DNA methylation as a factor in egg development and suggest that the epigenetic machinery responsible may be a therapeutic target.

    • Kathrin K. Geyer
    • Carlos M. Rodríguez López
    • Karl F. Hoffmann
    ArticleOpen Access
  • Quantum-mechanical predictions are generally probabilistic. Here, assuming freely chosen measurements, it is shown that enhanced predictions are not possible and, thus, randomness is inherent in quantum theory: a result that has applications in fields such as quantum cryptography.

    • Roger Colbeck
    • Renato Renner
    ArticleOpen Access
  • Many organisms are responding to a warming climate by shifts in spatial distribution. The poleward movement of silver hake,Merluccius bilinearis, over the last forty years is related to the position of the Gulf Stream and Atlantic meridional overturning circulation through changes in local bottom water temperature.

    • Janet A. Nye
    • Terrence M. Joyce
    • Jason S. Link
    Article
  • High critical temperature superconductors could be used to produce ideal electric power lines, but the misalignment of crystalline grain boundaries reduces current density. Here, pnictide superconductors are found to be more tolerant to misaligned grain boundaries than cuprates.

    • Takayoshi Katase
    • Yoshihiro Ishimaru
    • Hideo Hosono
    ArticleOpen Access
  • The inhibitor of apoptosis protein DIAP1 exists in an auto-inhibited conformation, but the details of its molecular interactions are poorly understood. Here, crystal structures reveal the auto-inhibition mechanism of DIAP1 and show how the active form of the protein binds to the effector caspase drICE.

    • Xiaochun Li
    • Jiawei Wang
    • Yigong Shi
    Article
  • Quantum computing has advantages over conventional computing, but the complexity of quantum algorithms creates technological challenges. Here, an architecture-independent technique, that simplifies adding control qubits to arbitrary quantum operations, is developed and demonstrated.

    • Xiao-Qi Zhou
    • Timothy C. Ralph
    • Jeremy L. O'Brien
    ArticleOpen Access
  • Male túngara frogs produce overlapping mating calls, which poses a challenge for the female frog to group and assign multiple auditory signals to the correct source. Farris and Ryan shows that, like humans, the female frogs compare and group signals using the smallest relative difference in call parameters.

    • Hamilton E. Farris
    • Michael J. Ryan
    Article
  • MITF is a transcription factor required for melanocyte development, which is activated in some melanomas. Zhao and colleagues show that USP13 removes ubiquitin from MITF, stabilizes MITF protein levels and enhances colony formation, suggesting that USP13 may be a therapeutic target in melanoma.

    • Xiansi Zhao
    • Brian Fiske
    • David E Fisher
    Article
  • Brillouin interactions between sound and light can excite mechanical resonances in photonic microsystems, with potential for sensing and frequency reference applications. The authors demonstrate experimental excitation of mechanical resonances ranging from 49 to 1,400 MHz using forward Brillouin scattering.

    • Gaurav Bahl
    • John Zehnpfennig
    • Tal Carmon
    Article