Browse Articles

Inositol polyphosphate 4 phosphatase regulates phosphoinositide signalling and is associated with an increased risk of asthma. Aichet al. show that, in a mouse model of airway inflammation, calpains degrade inositol polyphosphate 4 phosphatase resulting in exacerbated phosphoinositide 3-kinase signalling.

How DNA cytosine methylation affects gene expression inEscherichia coli is poorly understood. Here, the first genome-wide study of cytosine methylation in E. coliat single-base resolution reveals that cytosine methylation controls the expression of genes during the stationary growth phase.

CD44 is a cell surface protein that is a marker for stem cell-like cancer cells and has a role in invasion and metastasis. Here, epithelial splicing regulatory protein 1 is shown to generate a CD44 variant protein that enhances metastasis in a mouse model and protects cells from oxidative stress.

Ecological factors impact cooperative and competitive behaviour, creating social conflict. Here, predictions from a game-theory model together with observations of Taiwan yuhinas—a joint-nesting species where group members are unrelated—show that these birds are more cooperative in unfavourable environmental conditions.

De-differentiation and proliferation of vascular smooth muscle cells is thought to have a dominant role in vascular remodelling. Here, Tanget al. identify a new type of multipotent vascular stem cell in the blood vessel wall that contributes to this process, thereby challenging the established hypothesis.

The function of proteins is often regulated by their phosphorylation at specific amino-acid residues. The authors of this article have catalogued phosphoproteins and their phosphorylation sites in 14 rat organs and tissues, and provide these data as a resource for researchers.

Thed orbitals of transition metal compounds influence their crystallographic and physical properties. This study reports a unique structural transition in single crystals of the S=1/2 kagomé antiferromagnet, volborthite, whereby an unpaired electron 'switches' from one dorbital to another upon cooling.

Three-dimensional optical metamaterials provide a range of exciting features, such as broadband circular dichroism, yet their fabrication is challenging. Here, a broadband optical circular polarizer is presented based on twisted stacks of metasurfaces, avoiding the issues of three-dimensional fabrication.

Inbreeding reduces the fitness of birds and mammals, but at which stage in development this occurs is not always clear. Hemmingset al. show that when closely related zebra finches breed together, fertilisation proceeds normally, but the offspring are more likely to die during development of the embryo.

Fibre-optic waveguides are used to provide timing delays for different sensing and signal processing applications, but their transfer to on-chip platforms is a challenge. Here low-loss delay lines based on whispering-gallery spiral waveguides up to 27 m long are produced, presenting a scalable alternative.

σ-Complexes of transition metals are key intermediates in metal-mediated bond activation, but have traditionally been isolable only when chelating or when one of the participating atoms is hydrogen. Here, a complex is isolated with an unsupported borirene ligand bound not through the unsaturated C=C bond, but exclusively via a B–C single bond.

Transistors based on ions, as opposed to electrons, offer the promise of bridging the gap between technological and biological systems. Tybrandtet al. present logic gates based on ion bipolar junction transistors that operate at concentrations compatible with biological systems.

Proteins can undergo folding while being translated by the ribosome, and the extent of this folding is influenced by the rate at which amino acids are added to the nascent chain. This study provides a framework for predicting domain folding probabilities as a function of the kinetics of amino-acid addition.

Persistent organic pollutants can reach and pollute pristine environments, such as the Arctic Ocean, through atmospheric transport. This study shows that the oceanic biological pump can sequester atmospheric polychlorinated biphenyls, reducing the transport of pollutants to the Arctic Ocean.

Processes that regulate the mechanical and dynamic properties of actin cytoskeleton are important for multiple eukaryotic cell functions. In this study, using reconstituted crosslinked actin networks, organization is found to be determined by the competing kinetics of actin gelation and bundle formation.

The coupling that occurs between the structural and the magnetic properties of magnetic materials leads to a host of magnetoresponsive effects that are useful for potential technological applications. Here, a strong magnetostructural coupling that persists over a wide temperature range is reported in MnNiGe:Fe alloys.

Altered O-glycosylation of proteins is implicated in various human diseases. In this study, Tian and co-workers study mice that are deficient in the O-glycosylation enzyme Galnt1, and find reduced cell proliferation and organogenesis as well as increased endoplasmic reticulum stress.

Methods to study the structure of complex networks often rely on case-sensitive parameters that have limited applications. In this study, a new method—link salience—is used to classify network elements based on a consensus estimate of all nodes, finding generic topological features in many empirical networks.

The non-canonical Wnt signalling pathway mediates cell migration via the GTPase Rac but the detailed mechanism is unclear. In this study, the Daple protein is shown to regulate Wnt5a mediated activation of Rac, resulting in the formation of lamellipodia and cell migration.

Metformin is used to treat diabetes and its use has been associated with reduced cancer incidence, but the mechanism is unclear. In this study, metformin is shown to alter microRNA expression including an increase in mir-33a, which decreases the expression of the oncogenec-Myc.