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High-strength nanocrystalline materials come at the expense of tensile ductility, thermal stability, and electrical conductivity. Here the authors report a nanodispersion-in-nanograins strategy where ultra-nano-carbon was used to concurrently achieve above four mutually exclusive properties.
Stably silenced genes with methylated CpG at the promoter are refractory to current CRISPR activation systems. Here the authors create a more robust activation system, TETact that recruits DNA-demethylating TET1 with transcriptional activators.
Designing efficient bio-inspired vision systems remains a challenge. Here, the authors report a bio-inspired striate visual cortex with binocular and orientation selective receptive field based on self-powered memristor to enable machine vision with brisk edge and corner detection in the future applications.
Anterior face patches in the macaque have been assumed to represent face identity in a holistic manner. Here the authors show that the neural encoding of face identity in the anterior medial and anterior fundus face patches are instead driven principally by local features.
Understanding myelination is important for CNS plasticity and disease. Here the authors show exocytosis mediated by the vesicular SNARE proteins VAMP2/3 is involved in oligodendrocyte membrane expansion.
In this study, the authors compare the transmission dynamics of the Delta and Omicron SARS-CoV-2 variants using household data from Denmark. They find that Omicron has a higher secondary attack rate, and that the odds of infection with Omicron was higher than with Delta, particularly for vaccinated individuals.
Transition metal dichalcogenides (TMDCs) are interesting for nanophotonic applications due to their high refractive index and excitonic properties. Here, the authors report a scalable bottom-up fabrication method to realize arrays of TMDC metastructures showing dielectric optical modes and self-coupled exciton-polaritons.
Genetic mutations of insulin receptor (IR) cause severe insulin resistance syndromes with no current treatment or cure. Here, the authors present that insulin-independent IR activation mechanism by peptide agonist which activate non-functional IR mutants that cause the insulin resistance syndromes.
Here, Dekkers et al. characterize associations of 1528 gut metagenomic species with the plasma metabolome in 8583 participants of the SCAPIS Study, and find that gut microbiota explain up to 58% of the variance of individual plasma metabolites.
In this study, it is suggested that the daily PM10 level in East Asia is remotely controlled by the convection over the equatorial Indian Ocean and western Pacific. This tropical modulation explains up to 15% of daily PM10 variability in the region.
Stress granules are associated with neurodegenerative diseases. Here, Wang et al. found intracellular energy deficiencies trigger a unique type of granules and disrupt granule disassembly through 4EBP1/eIF4A.
Cross-scale energy transfers in collisionless plasmas help understanding involved mechanisms. Here, the authors show simultaneous macro- and micro-scale wave-ion interactions provide an efficient mechanism for cross-scale energy transfer and plasma energization in astrophysical and space plasmas.
In this study, the authors develop a method for estimation of SARS-CoV-2 community transmission rates based on a sentinel population of people seeking outpatient testing with recent symptom onset. This method has fewer operational delays than methods based on hospital data, and may be subject to fewer biases.
Bispecific antibodies can have advantages compared to antibody cocktails. Here, the authors engineer and characterize two different approaches for generating bispecific SARS-CoV-2 specific antibodies and find that only one design increases antigen-binding and virus neutralizing activities.
Wireless delivery of both light and pharmacological agents is important for optogenetic and other mechanistic experiments in the brain. Here the authors present a wireless real-time programmable optofluidic platform that enables optogenetics and photopharmacology experiments that require real-time precise control of light and drug delivery.
The beta-glucan receptor EphA2 is known to maintain mucosal immunity. Here, its role in modulating renal immunopathology via IL-23 signalling and ferroptotic cell death during candidiasis is characterised.
Scars are a significant problem caused by excess collagen in the skin. Here the authors develop a topical drug that reduces collagen stability and leads to improved scar appearance and stiffness in preclinical models.
An intracellular antenna that can truly enable probing, modulation or augmentation of biological cells remains an unmet challenge. Here, the authors present the Cell Rover, a magnetostrictive antenna that operates wirelessly inside a living cell and is compatible with 3D biological systems.
Multiple alternative splicing events in CD19 mRNA have been associated with resistance/relapse to CD19 CAR-T therapy in patients with B cell malignancies. Here, by combining patient data and a high-throughput mutagenesis screen, the authors identify single point mutations and RNA-binding proteins that can control CD19 splicing and be associated with CD19 CAR-T therapy resistance.
Ganglion cells classically respond to either light increase (ON) or decrease (OFF). Here, the authors show that during natural scene stimulation, a single ganglion cell can switch between ON and OFF depending on the visual context.