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IDO1-mediated tryptophan metabolism plays an important role in creating an immunosuppressive tumour microenvironment. Here, the authors show that deubiquitinase USP14 regulates immune suppression by inducing IDO1 stabilization and suggest USP14 as a potential therapeutic target to improve immunotherapy in colorectal cancer.
“Intracellular phase separation is emerging as a universal principle for organizing biochemical reactions in time and space. Here the authors show that PopZ condensate dynamics support cell division and using PopZ modular architecture, the tunable PopTag platform was developed to enable designer condensates.”
Center-surround receptive fields are typically considered to mediate edge detection. Here, by studying retinal bipolar cells responding to flashed and moving stimuli, the authors reveal an additional function: enhanced representation of newly appearing visual items.
Matson et al. performed single nucleus sequencing of the “spared” spinal cord tissue distal to an injury in mice. They found that spinocerebellar neurons expressed a pro-regenerative gene signature and showed axon outgrowth after injury.
There are limited predictive biomarkers for drug treatment responses in individuals with multiple sclerosis. Here using existing clinical trials data, the authors propose a deep-learning predictive enrichment strategy to identify which participants are most likely to respond to a treatment.
Frequency of cancer-related gene mutations can vary between populations. Here, the authors show differences in TP53 and other gene mutations between the U.S. and Chinese patients, and analyse differences in environmental risk factors to demonstrate that population-specific factors should be considered when discussing cancer risk.
Plant respiration at night is assumed to be temperature-controlled. Here, the authors show that temperature controls less than half of the variation in leaf respiration rate at night, and demonstrate how to account for such nocturnal variation in biosphere models.
Mutations in RAS oncogenes and related pathways are frequent in lung cancers. Here, the authors derive a RAS gene expression signature and a machine learning classifier to predict drug response and clinical outcomes in lung adenocarcinoma and other solid tumours, with improved performance over KRAS mutations alone.
DNA methyltransferase 3A, a mutated gene associated with hematologic malignancies in age-related clonal haematopoiesis lacks targeted therapies. Here, the authors screen carbon nanomaterials and find graphdiyne oxide binds to mutant cells and disrupts cellular processes with a therapeutic effect in vitro and in vivo.
Mechanisms ensuring developmental precision are poorly understood. Here Blanco-Obregon et al. report reciprocal feedback between Dilp8 and Ecdysone, two hormones required during a precise time window of Drosophila development for organ size adjustment.
A long-standing controversy surrounds low-angle nature of observed detachment faults within metamorphic core complexes. Here, the authors show that post-orogenic collapse of mountain belts can create a low-angle detachment, resolving the controversy.
Cytonemes are specialized filopodia-like structures known to be involved in signal transduction. Here they propose a new predictive model for cytoneme guidance in Hedgehog signaling, which is based on Ihog, Dally, and Dlp protein levels.
Accurate estimates of carbon fluxes are important to our understanding of the carbon cycle. Here, via model-data integration, the authors disentangle anthropogenic and environmental carbon flux contributions of terrestrial woody vegetation, and find that environmental processes are weaker and more susceptible to interannual variations and extreme events in the 21st century than previously estimated.
Here the authors present improved intramolecular sensors for β-arrestin2 and 1, which enable assessment of conformational changes of both isoforms in living cells. These reveal that the same GPCR induces differential conformational rearrangements that determine the functional diversity between the two β-arrestins.
Redβ annealase catalyses single-strand annealing homologous DNA recombination. Here, the authors present a cryo-EM structure of a Redβ annealing intermediate bound to two complementary 27mer oligonucleotides.
A new study sheds light on earthquake physics, showing that lithological and rheological heterogeneities in the rocks composing the seismogenic layer strongly influence seismicity distributions and earthquake scaling laws.
Motion vision is critical for survival. Here the authors show that motion detection occurs already in bipolar cells of the mouse retina, which may contribute to motion processing throughout the visual system.
The northern high latitude permafrost region has been an important contributor to the carbon sink since the 1980s. A new study finds that as tree cover increases, respiratory CO2 loss during late-growing season offsets photosynthetic CO2 uptake and leads to a slower rate of increasing annual net CO2 uptake.
Most humans procrastinate to some extent, despite adverse consequences. Here, the authors show that how much an individual procrastinates, both in the lab and at home, relates to brain signals that reflect temporal discounting of effort cost.
Astrochronology of a core in Maryland suggests that the onset of the Paleocene-Eocene Thermal Maximum (PETM) warming lasted about 6 thousand years. These data are more consistent with astronomical forcing than an extraterrestial trigger for the PETM.