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Insect pheromones can be degraded by the air pollutant ozone. Jiang et al. show that ozone-exposed male flies lose their pheromones and become less attractive to females. Additionally, ozone-exposed males exhibited increased male-male courtship behaviour as a result of reduced sex recognition.
Chiral nanostructures are in demand for various applications, but facile and scalable fabrication is a technical challenge. Here, the authors report polarization-directed chiral growth of complex spiral patterns by laser direct writing with vector beams.
Osteoclast differentiation is critical for bone homeostasis. The authors show the negative feedback regulation of BRD9-mediated chromatin remodeling on osteoclastogenesis via interferon beta signaling and its therapeutic potential for bone diseases.
Phosphoenolpyruvate carboxykinase 1 (Pck1) is an enzyme involved in glucose production that also regulates lipogenesis and has been linked to liver steatosis. Here the authors report that deficiency of Pck1 in the liver leads to nonalcoholic fatty liver disease via activation of the RhoA/PI3K/AKT pathway in a study with male mice.
A sustainable photocatalytic methane halogenation strategy is developed for methyl halide production using low-cost alkali halides over Cu-doped TiO2 nanostructures. Copper sites ultimately stabilize *CH3 to promote reaction with Cl− to form CH3Cl.
Dorzagliatin, which acts on the glucose sensor glucokinase, is a new class of anti-diabetic medicine. Here the authors report that in a phase I open-label trial co-administration of dorzagliatin and sitagliptin (a different class of anti-diabetic medicine) does not significantly change the pharmacokinetics of either medicine in patients with type 2 diabetes and obesity.
Who pays for climate change mitigation is an ongoing source of conflict. Here the authors examine how historical carbon emissions influences how much people will pay for climate change mitigation via an economic experiment.
It is unclear how cognitive computations are performed on sensory information. Here, neural evidence from working memory tasks suggests that the physical dimensions of cortical networks are used to update the status of sensory representations.
Exploring highly active and durable Ru-based electrocatalysts for acidic water oxidation is challenging. Here authors reported an ion-exchange adsorption strategy to regulate oxygen vacancies and Rh dopant, with a corresponding fundamental investigation on the lattice oxygen oxidation and the oxygen vacancy site.
Norepinephrine (NE) is a key neurotransmitter in the central nervous system of organisms however specifically tracking the transient NE dynamics with high spatiotemporal resolution in living systems remains a great challenge. Herein, the authors developed a small molecular fluorescent probe that can precisely anchor on neuronal cytomembranes and specifically respond to NE on a 100-ms timescale.
Specific detection of cellular superoxide is challenging. Here, the authors designed 1,2,4,5-tetrazine based fluorogenic probes for specific and sensitive imaging of superoxide, and applied them in high throughput screening of modulators of oxidative stress.
Preventing preterm birth and labor arrest requires safe and accurate uterine contraction monitoring. Here, the authors show that Electromyometrial Imaging (EMMI) can image 3D uterine contraction patterns dynamically in human labor, providing new insights into uterine maturation as labor progresses.
The corticostriatal dysfunction underlying Huntington’s disease remains incompletely understood. Here, the authors find increased intratelencephalic connectivity resulting from deficient cholinergic transmission in a mouse model of Huntington’s disease.
Continuous monitoring of SARS-CoV-2 variant properties is important for public health planning. Here, the authors use data from the United States and show that Omicron BA.4/5 subvariants, which became dominant in mid-2022, have stronger immune escape properties, but are no more severe, than the previously dominant BA.2.
An integrated phased array transmitter chip that uses an electronically controlled photonic network for millimeter-wave generation and beam formation is developed and used to demonstrate a fiber to wireless communication link.
Spin ice compounds are typically insulating and introducing carriers can destroy the spin ice state, making integration into electronic devices problematic. Here the authors report a transport response to an ice-rule-breaking transition in a heterostructure of a pyrochlore spin ice and a nonmagnetic metal.