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Chemotherapy priming sensitizes triple-negative breast cancers to immune checkpoint blockade. However, immune suppressive myeloid cells may impede its optimal effect. Here authors characterise the immune suppressive myeloid cells via single-cell analyses of immune cells from low dose chemotherapy treated breast tumours and identify STAT1 signalling as a regulator for immune suppressive state.
The molecular mechanisms underlying the development of thrombocytopenia in multiple myeloma (MM) remain to be explored. Here, the authors show an association of thrombocytopenia with poor prognosis in MM and identify serine as a key metabolic regulator of thrombocytopenia.
miRNAs typically bind to target mRNAs to induce their degradation but when base-pairing between miRNAs and the target RNAs are extended, miRNAs themselves can be degraded. Here, by employing AGO1-CLASH in Drosophila cells, the authors show that RNA sequence in AGO1 mRNA 3′UTR induces decay of miR-999.
Developmental plasticity allows organisms to match traits to their environment, however, there are few known molecular mechanisms underlying such plasticity. Here, the authors show that feeding morphs in adult Pristionchus nematodes are set during a critical window in juveniles and identify H4K5/12ac as the environmental information carrier.
Dudek et al. describe rectangular bacterial structures in the mouths of dolphins. Using various genomic and microscopy techniques, they show that the structures consist of bacterial cells that appear to divide along the longitudinal axis and display other unusual features.
The origin of homochirality in nature is an important but open question. Here, the authors provide insight into the physicochemical origin of homochirality through surface adsorption on the model of adlayers of achiral carbon monoxide molecules on an achiral Au(111) surface.
Magnetic reconnection is a fundamental energy release mechanism in space and laboratory plasmas. Here, the authors show persistent magnetic null-point reconnection in the solar corona at a scale of about 390 km.
The neocortex can filter out stimuli that distract us from our goals. Here the authors demonstrate in mice a mechanism of distractor filtering, in which top-down inputs from motor cortex to sensory cortex prevents the internal propagation of distractor stimuli.
Histopathological analysis is an essential tool in diagnosing colorectal cancer, but is limited in predicting prognosis and molecular profiles. Here, the authors designed a machine learning-based platform to predict multi-omics profiles and prognosis from pathology images.
In membranous nephropathy autoantibodies target podocytes of the kidney filter resulting in injury. Here the authors show that the ensuing proteostatic disturbances and proteinuria relate to aberrant interactions of non-functional UCH-L1 enzyme with the proteasome, curtailing its capacity.
Lattice-oxygen redox is pivotal for high oxygen evolution reaction (OER) activity. Here, LiNiO2, a unary 3d-transition metal oxide catalyst, exhibits superefficient activity during the OER due to the creation of double O 2p holes states, according to operando XAS, XRD, and Raman spectroscopy observations.
Water temperature influences lake ecosystems, but little is known about changes in its seasonality. This study shows that the timing of spring temperatures will arrive earlier whilst autumn temperatures will be delayed globally under climate change.
HER2 receptor aberrations are more common in breast DCIS premalignancy than in breast cancer. Here the authors identify a feedback circuit involving HER2 nucleocytoplasmic transport that may explain why some DCIS lesions progress and others do not.
Biocatalysis using immobilized enzymes is increasingly replacing traditional methods of manufacturing fine chemicals but heir industrial applications are limited by the low specific activity and poor stability. Here, the authors report a feasible strategy utilizing the synergistic bridging of triazoles and metal ions to induce the formation of porous enzyme-assembled hydrogels with increased activity.
In ice-rich Siberian permafrost sediments deposited during the Pleistocene, 33-74% of the organic carbon is mineral-bound favoured by the presence of reactive iron, which can reduce microbial CO2 production after thawing
Bacteria often express multiple adhesive proteins (adhesins) for biofilm formation, but it is often unclear whether adhesins have specialized or redundant roles. Here, the authors show that Vibrio cholerae uses two adhesins with overlapping but distinct functions to achieve robust adhesion to diverse surfaces.
Personal protective equipment used to prevent exposure to chemical warfare agents are devoid of detoxifying activity. Here, the authors report MOF aerogels via a hydrogen bonding-assisted interfacial engineering strategy for nerve agent decomposition.
During somitogenesis, the dynamic oscillation of the molecular clock is converted into static spatial patterns. Here, the authors show that persistent suppression of Tbx6 expression triggered by periodical Ripply1/2 gene expression is a key to this conversion.
Many microtubules in the mitotic spindle are made through microtubule branching. Here, the authors report a structural model of the augmin complex and insights into its role in microtubule branching.
The clinical benefits of chimaeric antigen receptor (CAR) T therapy are limited by ‘on-target, off-tumour’ effects. In this study, the authors describe a strategy that promotes the recognition of antigen on tumour, but not normal, cells by combining affinity tuning with inducible interleukin-12 expression.