Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain
the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in
Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles
and JavaScript.
This study demonstrates that an evolutionary conserved, autoregulatory ‘AT-hook’ domain of SWI/SNF regulates gene transcription and enhancer activation by modulating SWI/SNF intrinsic catalytic activity and is critical for cell lineage priming.
The authors identify a GYF domain-containing protein MHZ9 in rice, which regulates ethylene signaling by directly binding to OsEBF1/2 and other mRNAs thus regulating their translation efficiency in P-body via interacting with OsEIN2.
Cardiovascular disease diagnosis can be invasive and complex. Here, the authors present a flexible optoacoustic blood ‘stethoscope’ that noninvasively and continuously monitors cardiovascular health.
The sample size dependence of the glass transition in metallic glasses has hitherto remained elusive. Here, the authors show that, reducing sample size below 10 μm, the glass transition temperature can be depressed by as much as 40 K, thereby allowing attaining glasses with low energy states.
Corporate procurement initiatives, such as RE100, can increase their impact on the energy transition by formulating ambitious interim targets and sourcing requirements, and by orchestrating corporate interests in countries with less ambitious renewable energy targets.
New and existing paleoclimatic records show the rain-belt range of the Intertropical Convergence Zone (ITCZ) in the Indo-Asian-Australian monsoon region contracted to the northern low latitudes during the early Heinrich Stadial 1
Electromechanical characterization during atrial fibrillation (AF) remains a significant gap in the understanding of AF-related atrial myopathy. Here, the authors use non-invasive atrial electromechanical assessment during AF to identify early remodeling changes associated with underlying myopathy, which in the clinic decrease the probability of acute and mid-term successful rhythm control.
The scattering of light by small particles plays a central role in a myriad of fields. Here, the authors demonstrate a super dipole resonance that arises when two resonant modes of a small particle interfere, overcoming a widely accepted limitation to the cross section.
The dihalogenation of alkenes is a significant chemical reaction, but its reaction conditions are demanding. Here, the authors show a photocatalytically assisted shuttle strategy using perovskite quantum dot catalysts for reversible vicinal dihalogenation under visible light illumination.
Achieving high-efficiency alkaline water electrolyzer operating at large current densities remains a critical challenge. Here the authors report Ru nanoparticle-perturbed Cu nanoplatelets as cathode for hydrogen evolution reaction coupled with stainless steel anode in alkaline electrolyzer with high performance, long-term stability and relatively low-capital expenditures.
Achalasia is a rare motility disorder of the esophagus resulting from abnormal immune responses, but the immunologic mechanism is unclear. Here the authors use scRNA-seq of PBMC and esophageal lower sphincter tissue and find C1QC+ macrophages and tissue-resident memory T cells with expanded compositions and altered transcriptional profiles in achalasia.
Functional divergence of CYP76AK subfamily, accompanied by oxidation variations at C-20, leads to diverse abietane-type diterpenoids in Salvia species. Enzyme activity loss contributes to this unique chemical diversity within the lineage.
The protein PR1 is crucial for plant immunity but has unclear bioactivity. Here PR1 is shown to release a phytocytokine CAPE and trigger systemic acquired resistance (SAR) via a caspase-like enzyme specific for CAPE production (ESCAPE).
KRAS mutations are associated with an immunosuppressive microenvironment in patients with colorectal cancer (CRC). Here the authors show that knockout of SLC25A22, a mitochondrial glutamate carrier, reverts KRAS-mediated immunosuppression in preclinical CRC models, by suppressing CXCL1 production and impairing MDSC recruitment.
Envelope glycoproteins from Asia prevalent HIV-1 subtypes, CRF01_AE and CRF07_BC, remain less explored. Here, the authors reveal the unique features of their V1 regions, associate them with the resistance to certain broad neutralising antibodies (bNAbs), and unravel the epitope and mechanism of a bNAb from CRF01_AE infected individuals.
Here, the authors show the dynamic tuning of the moiré potential in a WS2/WSe2 heterobilayer by gate voltage and optical power, allowing for simultaneous observation of the first and second order Stark shift for the ground state and first excited state, respectively, of the moiré trapped exciton.
Here the authors show that myonectin functions as a protective factor against age-associated, disuse-induced or steroid-induced muscle atrophy, suggesting that myonectin represents a therapeutic target for preventing skeletal muscle dysfunction.
The Ycf48 accessory factor is important for the assembly and repair of the photosystem II (PSII) complex of oxygenic photosynthesis. Here, the authors show that Ycf48 occupies the binding site of the oxygen evolving Mn cluster early in PSII biogenesis.
The progress development of multispectral camouflage technologies has been limited to the choice of materials and structural design. Here, authors propose a material-informatics-based inverse design framework to efficiently design multilayer metamaterials with satisfying visible-infrared camouflage performance.
Biological rhythms influence physiology and morphogenesis, though how these influence periodic pattern formation remains unclear. Here the authors show that the infradian rhythm observed in zigzag hairs is regulated by hair progenitors and their micro-niche and influences hair shaft bending.