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The genetics and clinical consequences of resting heart rate (RHR) remain incompletely understood. Here, the authors discover new genetic variants associated with RHR and find that higher genetically predicted RHR decreases risk of atrial fibrillation and ischemic stroke.
Ligands and additives are often utilized to stabilize low-valent catalytic metal species experimentally, while their role in suppressing metal deposition has been less studied. Here, the authors report an on-cycle mechanism for CoCl2bpy2 catalyzed Negishi-type cross-coupling describing a full catalytic cycle for this reaction using multiple spectroscopic studies.
Understanding the genetic basis of rubber tree domestication is critical for improving natural rubber production. Here, the authors assemble the genome of the rubber tree clone CATAS8-79 and conduct population and genetic association analyses to reveal the function of phytosulfokine in regulating number of laticifer rings.
Controlling the self-assembly on noncovalent components is possible by suppressing entropy loss with templates but this is challenging for covalent components. Here the authors employed directing groups to endow purely covalent molecular building blocks with different conformations which favor the formation of specific self-assembled products.
Using high-resolution model experiments, the authors identify the rapid spreading of mid-depth density anomalies from the Labrador to the Irminger Sea as a prime mechanism in the generation of decadal changes in the Atlantic overturning circulation.
Gallium promoted metal catalysts are promising for methanol synthesis at ambient pressures, but their surface structures remain unknown. Here, the authors monitor in situ the copper-gallium model catalyst in the reaction atmosphere and show the formation of gallium-oxide islands embedded into the copper surface.
Iron oxide magnetic nanoparticles are utilized in Fe(II)-induced ferroptosis for cancer therapy, but controlling the Fe(II) release from magnetic nanoparticles remains challenging. Here the authors reveal that photothermia at the nanoscale can remotely trigger the degradation of magnetic nanoparticles, leading to Fe(II) release and a synergistic photothermo-ferroptotic therapy.
Metabolic pressure, in particular the lack of methionine availability, on tumor-infiltrating CD8 + T cells is associated with T cell dysfunction. Since tumor cells rely on SLC43A2 for methionine uptake, here the authors design a nanoplatform for CRISPR/Cas9 mediated silencing of SLC43A2 and STING activation, restoring anti-tumor T cell immune responses.
The cytoplasmic kinase BIK1 plays a central role in immune signaling and its protein homeostasis is maintained by the interplay of the ubiquitin ligases RGLG1/2 and PUB25 - RGLG1/2 suppress PUB25-mediated BIK1 protein degradation.
Limited tumor penetration and low cellular uptake of current nanocarriers reduce the efficacy of anticancer drugs against TNBC. Here the authors develop biomimetic head/hollow tail nanorobots and show their efficacy at remodeling the dense tumor stroma in TNBC.
Suitable in vitro models allowing to assess Plasmodium liver stage development are still limited. Here, Yang et al. show that hepatocytes derived from human hepatocyte organoids (HepOrgs) can support P. falciparum development. This allowed for the identification and validation of the importance of the host factor, scavenger receptor B1 (SRB1), in parasite development.
Protein-protein interactions (PPIs) are crucial for biological functions and have applications ranging from drug design to synthetic cell circuits. Here the authors develop an assay and computational methods to identify more orthogonal coiled-coil pairs, critical for biological processes and drug design.
Newly formed endosomes mature into early endosomes by shedding one protein and acquiring another. Here, the authors describe a trigger-and-convert mechanism driven by endosomal collisions and fusions that govern timeliness in ensemble maturations.
Soft grippers can emulate human hands, but it remains challenging to achieve multiple capability in manipulating various objects in one design. Hong et al. utilize a kirigami gripper with controllable and programmable trajectories to manipulate objects spanning from ultra-soft to ultra-strong with high precision.
Separating active cathode materials from current collectors poses a critical challenge in battery recycling. Here, the authors develop a facile strategy that relies on a reaction-passivation mechanism to effectively separate the aluminum foil and cathode active material in spent lithium-ion batteries.
Neuberger et al. report the structure of human channel TRPV6 in complex with a cannabinoid inhibitor tetrahydrocannabivarin (THCV) and explore the pathway taken by the drug to reach binding sites in the portals that connect the membrane environment to the central cavity of the ion channel pore.
The authors observe the signatures of quadrupolar excitons in a WSe2-WS2-WSe2 trilayer moiré superlattice, originating from the hybridization of the WSe2 valence moiré flatbands. They further use electrostatic gating to reveal a hybridized interlayer Mott insulator state, with holes shared between the two WSe2 layers but laterally confined in moiré superlattices.
In this work, the authors highlight that conserved receptor binding segments of class B GPCR ligands have a dual nature: they serve as amyloid-prone regions involved in pH-dependent conversion from secretory amyloid fibrils to the functional folded form.
Multiplexed imaging studies are typically focused on cell-level phenotypes. Here, the authors propose Pixie, a cross-platform and open-source pipeline that achieves robust and quantitative annotation of both pixel-level and cell-level features in multiplexed imaging data.