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Mid-infrared light emitting diodes (LEDs) based on black phosphorus (BP) have shown promising performance, but they are usually limited by the environmental instability of the material. Here, the authors extrapolate a room-temperature operational lifetime of BP LEDs up to ~ 15,000 h via Al2O3 passivation and nitrogen seal packaging.
The heterogeneity of androgen receptor (AR) gene alterations across metastases in prostate cancer remains unresolved. Here, the authors characterise AR genomic complexity across spatially separated lethal metastases from 10 prostate cancer patients and investigate how AR alterations evolve.
In the US, states vary in their efforts to address climate change. Stronger state climate policies reduce CO2 emissions without harming the economy, but these reductions are unlikely to meet the goals in the Paris Climate Accord.
Ocean oxygenation regulates respired carbon storage and atmospheric CO2. This study applied a novel analysis using magnetic nanoparticle fossils and found glacial Indian Ocean oxygen decline and carbon accumulation to explain recent climate cycles.
MTH1 hydrolyzes oxidized nucleotides to prevent their mis-incorporation into DNA under oxidative stress. Here, the authors show that MTH1 is expressed in platelets and its deficiency increases mitochondrial DNA oxidative damage, impairs platelet function and hemostasis.
Modelling of riverine plastic exports finds microplastics dominate in areas with many sewage systems and macroplastics where waste is mismanaged. In some areas both plastics are important. Reduction at source is needed.
Eukaryotic transcription involves the formation of subnuclear hubs that enrich transcriptional machinery. Here the authors show that the hubs undergo stepwise modifications to fuel a burst of transcription rather than having a stable composition.
The serial interval (time between symptom onset in an infector and infectee) is usually estimated from contact tracing data, but this is not always available. Here, the authors develop a method for estimation of serial intervals using whole genome sequencing data and apply it data from clusters of SARS-CoV-2 in Victoria, Australia.
Verticillium dahliae, a soil-borne fungal pathogen, causes vascular wilt in a wide variety of economically important crops. This study reveals a sophisticated pathogenic mechanism of VdUlpB-deSUMOylated enolase to facilate fungal virulence by derepressing the expression of the effector VdSCP8.
Catalytic enantioselective introduction of a propargyl group is an important carbon–carbon forming reactions but only few Cu- or Ni-catalyzed protocols with limited reaction modes are known. Here, the authors describe a photoredox/cobalt-catalyzed propargyl addition to aldehydes via propargyl radicals which enables the construction of a broad scope of homopropargyl alcohols.
Invasive extravillous trophoblast cells are a key feature of placentation and successful pregnancy. Here, the authors identify transcription factors and regulatory mechanisms critical for extravillous trophoblast cell lineage development.
It is known that chloride anions cause severe anode corrosion during seawater electrolysis. Here we found that bromide in seawater is even more harmful to Ni-based anodes, causing the spalling of the catalyst layer and the formation of shallow-wide pits on the substrate, leading to performance degradation.
It is interesting and important to understand how the properties of nuclei and their stability change with temperature. Here the authors report their theoretical study of hot nuclei and the drip lines that limit the nuclear existence at finite temperature.
Lithium niobate (LN) is difficult to process via dry etching. Here, authors demonstrate the fabrication of deeply etched, tightly confining, low loss LN photonic integrated circuits with losses 4 dB/m using diamond like carbon as a hard mask.
Brain mitochondria play crucial roles that influence cognition, yet their diversity is often overlooked. This study in mice identifies distinct mitochondrial phenotypes distributed as large-scale networks, accounting for a large portion of animal-to-animal behavioural variation.
A program regulating replication origins ensures the exact duplication of vertebrate genomes. The authors identify a combination of guanine-rich motifs, known to form secondary DNA structures, which are sufficient to assemble efficient replication origins.
Cell division and stem cell maintenance are tightly linked. Here they show that in the hair follicle an epigenetic mechanism maintains mesenchymal niche dormancy in a highly proliferative microenvironment while repurposing mitogenic signaling to orchestrate the hair cycle clock.
Achieving strength and toughness synergy via microstructure design is challenging in materials science. Here, the authors construct a bamboo-like dual-phase copper-boron structure that has unique mechanical response resulting in simultaneous increase in hardness, strength, and ductility.
Here authors show that gamma/beta double polymorph Ga2O3 structures exhibit unprecedently high radiation tolerance accommodating disorder equivalent to hundreds of displacements per atom. Thus, such Ga2O3 structures benchmark a new class of radiation tolerant semiconductors.
α1-adrenergic receptors (α1- AR) play critical roles in the cardiovascular and nervous systems. Here, the authors report molecular insights into the mechanisms underlying the discrimination between α1A-AR and α1B-AR by the agonist A61603.