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Oceanic evasion, which mainly occurs in the Marginal Ice Zone, is the main cause of the summertime maximum of gaseous elemental mercury in the central Arctic Ocean
The use of automated tools to reconstruct lipid metabolic pathways is not warranted in plants. Here, the authors construct Plant Lipid Module for Arabidopsis rosette using constraint-based modeling, demonstrate its integration in other plant metabolic models, and use it to dissect the genetic architecture of lipid metabolism.
Fungal pathogens are recognised and phagocytosed by macrophages in the early stages of infection. Here, Onyishi et al. identify a crosstalk between Toll Like Receptor 4 and Macrophage Scavenger Receptor 1 in the regulation of Cryptococcus neoformans uptake.
Kagome superconductors are a platform for intertwined condensed matter phenomena that may be mediated by band topology. Here, authors use ARPES and DFT to identify type-II Dirac nodal lines, flat bands, topologically non-trivial surface states and signatures of nematicity in the kagome compound RbTi3Bi5.
This study unified cnidarian microbiome data from 186 studies (~ 6.5 billion sequence reads), providing novel insights into cnidarian microbial communities and highlighting key bacteria across sub-phylum, geography, depth and microhabitat. Understanding factors governing microbiome health will support ongoing and future coral preservation efforts.
This study links the genomic basis of behavioral variation to specific cell populations in the brain. Here, authors find evidence for involvement of neural stem cells in the evolution and expression of bower-building behavior in cichlid fishes.
Combination of immune checkpoint inhibitors with anti-angiogenic targeted therapy has shown efficacy in some solid tumours. Here the authors report the results of a phase 2 trial of camrelizumab (anti-PD1) plus apatinib as a second-line or later-line treatment regimen in platinum-resistant (cohort 1) or PD-1 inhibitor-resistant (cohort 2) Recurrent/Metastatic Nasopharyngeal Carcinoma patients.
Electrospray deposition is a promising technique for depositing functional coatings at the micro-/nano-scale. Here, the authors establish the necessary conditions for high efficiency electrospray deposition of small targets, establishing promise as an alternative to other conformal coating methods.
Organosilanes bearing an enantioenriched silicon center are important in many fields of chemistry. Here, the authors report a dynamic kinetic silyletherification racemic chlorosilanes with (S)- lactates, leading to asymmetric synthesis of silylethers.
By coupling two quantum dots via a superconductor-semiconductor hybrid region in a 2D electron gas, the authors achieve efficient splitting of Cooper pairs. Further, by applying a magnetic field perpendicular to the spin-orbit field, they can induce and measure large triplet correlations in the Cooper pair splitting process.
Stability issues remain a critical challenge for perovskite solar cells towards commercialisation. Here, the authors analyse a large homogeneous dataset of Maximum Power Point Tracking operational ageing data and find a correlation between maximum power conversion efficiency and its relative loss.
The search for efficient methods for the enantioselective synthesis of cyano-containing molecules is important but synthesis methods are often limited by the need of toxic cyano salts or reduction with hydrogen gas. Here the authors report the efficient and selective access to β-cyano carboxylic esters which can be easily converted into γ-aminobutyric acid derivatives with high optical purities.
An ideal holographic camera acquires depth information about an object by measuring the light field. Here, the authors present a reference-free single-shot holographic image sensor that freely focuses the image of real-world objects via reciprocal diffractive imaging.
Metabolic reprogramming is a common indicator of the tumour microenvironment. Here the authors develop the METAflux framework to predict metabolic fluxes from single cell RNA-seq data.
CLC transporters are regulated by nucleotides and phospholipids. Here cryo-EM structure of Arabidopsis CLCa in complex with ATP and PIP2 and electrophysiological analysis suggests the underlying regulatory mechanisms of both nucleotides and phospholipids.
Testing general relativity with optical clocks is important both as a fundamental test and for metrological applications. Here, a vertical linear array of 5 separate ensembles of strontium atoms trapped in a single optical lattice is used to perform a blinded lab-based test of the gravitational redshift at the mm to cm scale.
Engineering polyketide synthases can be challenging due to the absence of efficient high-throughput methods. Here, the authors used a solubility biosensor to identify stable variants from libraries of modified polyketide synthases.
Antibiotic resistance is a risk for human and pig health. Here, the authors profile the antibiotic resistome of the pig lower respiratory tract and evaluate potential mobile genetic elements mediating antibiotic resistance gene transfer.
Multiplexed DNA FISH technologies are powerful tools to reveal chromatin spatial organisation. Here, the authors developed SnapFISH, a computational pipeline to identify chromatin loops from multiplexed DNA FISH data.
TMEM16F is a Ca2+ activated ion channel and lipid scramblase involved in cell fusion. Here authors determine cryo-EM structures of TMEM16F with or without bound blockers, such as the FDA-approved drug niclosamide.