Articles

Frequency comb synthesizers are important for metrology, but they have been difficult to use as frequency rulers in the terahertz region due to their low power. Consolinoet al. phase-lock a quantum cascade laser to a free-space-propagating terahertz comb, demonstrating that they can overcome this limitation.

The iron–sulphur enzyme IspH catalyses the final step of the methylerythritol phosphate isoprenoid biosynthesis pathway. Spanet al. report that IspH can hydrate acetylenes to aldehydes and ketones, in addition to its role as a 2H⁺/2e⁻reductase.

Spin dynamics in magnetic materials can be driven by ultrafast light pulses, resulting in transient magnetization changes on femtosecond timescales. Rudolphet al. find that in magnetic trilayers the magnetization of one layer can be enhanced by superdiffusive spin currents from adjacent layers.

Blind quantum computation is a protocol that permits an algorithm, its input and output to be kept secret from the owner of the computational resource doing the calculation. Morimae and Fujii propose a strategy for topologically protected fault-tolerant blind quantum computation that is robust to environmental noise.

Reconstructing short-term plate-motion changes through time provides important geodynamical information, but data noise is a problem at fine temporal resolution. This study presents a trans-dimensional hierarchical Bayesian framework that eliminates noise without loss of temporal resolution.

The paratympanic organ in the avian middle ear is similar to the fish spiracular organ, but its developmental origin is unresolved. O'Neillet al. use fate mapping techniques to show that the avian paratympanic organ and its afferent neurons arise from a previously undiscovered neurogenic placode.

Many drugs exist that target the β-adrenergic receptor, but they have different efficacies. Kofukuet al. use NMR to show that methionine 82 in the transmembrane domain undergoes conformational changes depending on whether agonists or inverse agonists are bound, explaining the differential drug efficacy.

Sex pheromones are used by adult members of a species to attract a mate. This study proposes that the larvae of the cotton leafwormSpodoptera littoralisare attracted to sex pheromones and prefer a food source containing it, suggesting an alternative use of the sex pheromone to trigger food search in caterpillars.

Mast cells are mediators of type I allergic disease and inflammation. Here, Kurashimaet al. show that mast cells are increased in the colons of mice with colitis, and that activation of the cells and subsequent inflammation can be blocked by inhibition of the purinoceptor, P2X7.

The dalesconol natural products are biosynthesised in an enantiomeric excess of 67%, rather than as a single enantiomer or a racemate. Tanet al. report that this unusual enantioselectivity is a result of the dominance of particular conformers of naphthol dimer intermediates.

Methyltransferases modify cellular proteins in addition to DNA and histones. These authors identify a new family of lysine-specific methyltransferases and show that a member of this family, which is associated with tumour metastasis, methylates the ATP-dependent protein chaperone VCP/p97.

Methane is an important anthropogenic greenhouse gas and is thought to be produced by industrial processes and prokaryotic methanogenic Archaea. In this study, the saprotrophic fungi,Basidiomycetes, is shown to produce methane in the absence of methanogenic Archaea.

One of the obstacles to improving the efficiency of organic photovoltaic solar cells is the recombination of polaron pairs at the interface between donor and acceptor molecules. By doping cells with galvinoxyl radicals, Zhanget al. demonstrate a mechanism that overcomes this problem via a spin-flip process.

Class A seven transmembrane helical receptors harbour vestibules at the entrance to the ligand-binding domain. Here, Bocket al. use probes to monitor the conformation of the M2 muscarinic receptor and show that the vestibule alters the extent of receptor movement.

Charge stripe order has been predicted to be the ground state for the parent compounds of copper oxide superconductors. Using resonant X-ray diffraction, Schüßler-Lagenheineet al. probe the surface region of 12 percent doped La_2−xSr_xCuO₄, and observe charge-stripe order.

Multi-partite entanglement is essential not only to understand large quantum ensembles but also to build useful quantum technologies. Armstronget al. demonstrate multimode entanglement of up to eight modes using programmable virtual networks based on linear optics that can be switched in real time.

The optical transitions that occur in rare-earth-doped crystals offer promise for quantum information storage and processing. Kolesovet al.report the optical detection of a single praseodymium ion residing in a crystal host by using an excited-state absorption process to enhance its fluorescence yield.

Supramolecular interactions allow some small molecules to self-assemble into nanofibres and hydrogels in aqueous environments. Gaoet al.report a hydrogelator that forms fluorescent nanofibres within cells, leading to the visualization of their self-assembly at the endoplasmic reticulum.

Small- and intermediate-conductance K⁺channels are activated by calcium-bound calmodulin and modulated by small molecules. In this study, a functional binding pocket for the 1-EBIO class of modulators is described and is located at the calmodulin-channel interface.

The torque contributions exerted by spin-polarized currents on magnetic structures are not fully understood due to the difficulty in discerning their relative weight. Pollardet al. propose a novel method to directly determine the value of the competing spin transfer torques by in-situLorentz microscopy.