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The authors demonstrate ultrabroadband, polarisation-independent directional control of thermal radiation using a pixelated micro-emitter, and produce large emissivity contrast at different directions, with potential applications to radiative cooling, infrared spectroscopy and thermophotovoltaics.
Recent studies show that targeting CXCL12 can improve the effect of radiotherapy (RT) in preclinical models of glioblastoma (GBM). Here, the authors report the safety and preliminary efficacy of a phase I/II clinical trial investigating an L-RNA aptamer-based CXCL12 inhibitor (NOX-A12) in combination with RT in patients with newly-diagnosed GBM.
Here, in a follow-up of a clinical study, the authors show that protein pacing and intermittent fasting improves gut symptomatology and microbial diversity, as well as reduces visceral fat compared to a heart-healthy, calorie-restricted diet matched for overall energy intake and expenditure in free-living humans.
Lee et al. developed ultrathin metallic (metal filling ratios of > 70 %) metamaterials that exhibit perfect transmission at a specific radar frequency. These characteristics enable microwave transparent, low-sheet-resistance radar heaters for safe autonomous driving in extreme weather.
Detection and identification of microplastics (MPs) in environmental samples is hampered by the need for isolation and pretreatment methods. Here, the authors combine porous Ag substrates with self-attention neural networks to directly identify six types of MPs in environmental samples.
Gene therapy is a rapidly growing field, but is hindered by efficacy and safety concerns, including those related to delivery methods. Here, inspired by the use of foam in the delivery of pharmaceuticals, Dr. Stephan and colleagues formulated foam as a safe and effective delivery platform for gene therapy.
Wastewater surveillance has the potential to be used for early detection of new SARS-CoV-2 lineages. Here, the authors present Crykey, a computational method for detecting cryptic SARS-CoV-2 mutations in wastewater that co-occur on the same sequencing read, potentially representing new lineages.
Attributing spatially heterogeneous heat stress trends to water vapor pressure changes driven by climate change-induced rapid warming in high-latitudes of East Asia, the authors predict widespread and uniform future heat stress in eastern China.
Large-scale 2D hexagonal boron nitride (hBN) grown via chemical vapour deposition (CVD) has strategic importance for various applications of 2D materials. Here, the authors analyse the structural and electrical properties of commercially available CVD hBN from 9 popular suppliers and compare the results with mechanically exfoliated hBN and in-house CVD hBN.
Here, the authors reveal the protonation of a single membrane embedded glutamate residue within the homodimer of the efflux transporter EmrE modulates the structure and dynamics in an allosteric manner using NMR spectroscopy.
Biological cofactors such as dihydronicotinamides are exploited by extant enzymes as hydride transfer agents and electron carriers but are generally inefficient to facilitate any reactions on their own. Here, the authors report short peptide-based amyloid nanotubes featuring exposed arrays of cationic and hydrophobic residues that can bind small hydride transfer agents (NaBH4) to facilitate efficient reduction of ester substrates in water.
Memory CD8+ T cells persist poorly in MHCII-deficient mice. Here the authors show that this CD8+ T cell attrition is not caused by a lack of CD4+ T cell help, as previously proposed, but by chronic IFN-γ signals derived from endogenous colonic CD8+ T cells.
The authors demonstrate all-spin synapses and neurons using domain wall-magnetic tunnel junctions, utilizing synergistic spin-orbit torque and Dzyaloshinskii-Moriya interaction. The intrinsic linearity is required for compact and energy-efficient bio-inspired hardware for neuromorphic computing.
Hypericum plants contain complex compounds with promising medicinal properties. Here, the authors report a pair of enzymes catalyzing prenylation and regiodivergent cyclization. The forged scaffolds are characteristic of hyperforin analogs.
Transition-metal catalyzed cross-electrophile coupling (XEC) is a powerful tool for the construction of molecules but XEC between carbon electrophile and chlorosilanes to access organosilicon compounds remains underdeveloped. Here the authors disclose a highly efficient cobalt-catalyzed cross-electrophile alkynylation of a broad range of unactivated chlorosilanes with alkynyl sulfides as a stable and practical alkynyl electrophiles.
Researchers have developed a noninvasive retina prosthesis based on ultrasound for treating blindness. This device uses ultrasound waves to stimulate the retina, creating artificial vision confirmed through behavior tests, offering a safer alternative to invasive treatments.
Efflux pumps confer antibiotic resistance by coupling proton import with drug export. In this work, the authors uncover the proton-coupled transport mechanism for the clinically relevant efflux pump NorA from the pathogenic bacterium S. aureus.
At the tetrad stage, OsSRF8 interacts with OsINP1 to promote the formation of aperture plasma membrane protrusion (APMP). Then, the OsINP1-OsSRF8 protein complex recruits OsDAF1 to the APMP site and co-regulate pollen aperture formation in rice.
Quantum emitters in Si show promise for applications in quantum information processing and communication due to their potential as spin-photon interfaces. Jhuria et al. report the formation of selected telecom emitters in Si using local writing and erasing by fs laser pulses and annealing in a hydrogen atmosphere.
COVID-19 vaccines reduce the risk of severe disease in young people, but the absolute risk is low, and side effects have been reported. Here, the authors use data on 5–17 year olds in England to assess the overall risk-benefit profile of the vaccines.