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The role of the cerebellum in language processing remains unclear. Here, the authors use a biologically-constrained artificial cerebellar neural network to reveal a dual role of single circuit computation in syntax and word prediction.
Via the first-principles calculations and experimental verifications, a guiding principle is established to design heteroatom-doped-graphene-supported Ca single-atom carbon nanomaterials for efficient non-dissociative solid-state hydrogen storage.
Traditional mineralization of organic pollutants requires an excessive input of chemicals and causes undesirable carbon emissions. Here, authors report a nanoconfinement strategy to alter the carbon transfer pathway of phenol removal from ring opening route to oligomerization route.
Although most patients achieve complete response after standard-of-care treatment, residual disease in patients with nasopharyngeal carcinoma is associated with poor prognosis. Here the authors report the results of a phase 2 trial of toripalimab (anti-PD1) plus capecitabine for patients with residual nasopharyngeal carcinoma.
The ecology of Ebola virus (EBOV) is still largely unclear. Here, the authors show that Angolan freetailed bats are selectively permissive to EBOV infection, but not to other filoviruses, and demonstrate EBOV placental tissue tropism indicating potential horizontal and vertical transmission between conspecifics.
Hypothetical dark photon (DP) dark matter (DM) and axion DM might resonantly convert into electromagnetic waves in the solar corona. Here, the authors show upper limits on the axion-photon coupling and on the kinetic mixing coupling of DPDM and photon within 30-80 MHz in the solar corona radio observations.
Dysfunction in dorsal striatum, a brain region important for reward and habits, is linked to opioid use disorder (OUD). Here, authors delineate diverse cell populations in human dorsal striatum, revealing altered inflammatory and DNA damage signaling in OUD.
New antimalarials are urgently needed. Here, the authors identify Open Source Malaria compound, OSMS-106, as a reaction hijacking inhibitor of the malaria parasite protein synthesis machinery, with potential use for treatment and prophylaxis.
Flexible Ag2Se possesses promising near-room-temperature thermoelectric performance, while trade-off in thermoelectric performance and flexibility enhances its practical utility. Here, the authors fabricate polycrystalline Ag2Se-based thin film with a high ZT of 1.27 at 363 K by Te doping.
Pertussis immunisation for pregnant women has been introduced to protect newborns, but immunological evidence suggests that this lessens subsequent infant immune response to vaccination. Here, the authors assess the epidemiological impacts of both consequences of maternal immunisation on infant infection.
The development of practical Ca metal batteries has been hindered by the cathode chemistry. Here, the authors report a rechargeable Ca/Cl2 battery, which involves the reversible cathode redox reaction between CaCl2 and Cl2.
This study uncovers the specialized function of previously elusive BCL7 subunits of SWI/SNF complexes in eukaryotes and reveals the mechanism whereby plants memorize the juvenile identity through SWI/SNF-mediated control of chromatin accessibility.
It is unclear whether naturally evolved de novo proteins have stable, folded structures. Here, systematic identification and structural modeling of de novo genes, this study reveals that a small subset of these proteins may have well-folded structures, and were likely born with these structures.
Topological slow light is of fundamental importance for science and technology. Here the authors reveal that the presence of magnetic phase vortices along with glide symmetric interfaces is crucial for the existence of slow light modes in topological valley photonic crystal waveguide.
Dimethyl fumarate (DMF) is an anti-inflammatory drug proposed as a treatment for COVID19. Here the results are reported from a randomised trial testing DMF treatment in 713 patients hospitalised with COVID-19. DMF was not associated with any improvement in day 5 outcomes.
Conventional CRISPR-based approaches to monitor genomic loci can be hampered by high background and nonspecific nucleolar signal. Here, the authors propose a fluorogenic CRISPR (fCRISPR) tool that allows for high-contrast and sensitive imaging of genomic DNA.
2D bilayers have recently attracted significant attention due to fundamental properties like interlayer excitons and interfacial ferroelectricity. Here, the authors report a density functional theory approach to identify 2586 stable homobilayer systems and calculate their stacking-dependent electronic, magnetic and vibrational properties.
Based on differently-oriented MAPbBr3 single-crystal wafers, the authors revealed anisotropic carrier dynamics by using angle-resolved pump-probe technique, and the microstructural mechanism of the femtosecond laser-induced emission enhancement
Ionic skins have potential in long-term physiological monitoring, but do not always achieve a desirable balance of viscosity and elasticity. Here, the authors report a material with hierarchical topological entanglements allowing desirable viscoelastic properties.