The monoclonal antibody 3B5H10 that recognizes diffuse mutant huntingtin predicts cell death in primary striatal neurons. Biochemical and biophysical analyses reveal that the 3B5H10 epitope is exposed in a monomeric state, identifying this specific conformation as a toxic agent in Huntington's disease.
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Tanaka, M. Tracking a toxic polyQ epitope. Nat Chem Biol 7, 861–862 (2011). https://doi.org/10.1038/nchembio.718
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DOI: https://doi.org/10.1038/nchembio.718
