In this issue - pv
doi:10.1038/nchembio0109-v
Table of contents
January 2009, Volume 5 No 1 pp1-59
About the coverTop of page
Editorial
New in 2009 - p1
doi:10.1038/nchembio0109-1
As we enter our fifth year of publication, Nature Chemical Biology offers new content and functionality for the chemical biology community.
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Elements
Monell Chemical Senses Center - p2
Catherine Goodman
doi:10.1038/nchembio0109-2
A taste of the research at the Monell Center reveals an increased understanding of how we perceive and integrate chemical cues.
Full Text - Monell Chemical Senses Center | PDF (88 KB) - Monell Chemical Senses Center
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News and Views
The proteasome makes sense of mixed signals - pp3 - 4
Thomas J Wandless
doi:10.1038/nchembio0109-3
Protein ubiquitination is an important degradative signal, yet not all ubiquitinated proteins are degraded. Recent results reveal insights into the proteasome's strategy for integrating biophysical signals when choosing substrates for degradation.
Full Text - The proteasome makes sense of mixed signals | PDF (1,485 KB) - The proteasome makes sense of mixed signals
See also: Article by Prakash et al.
Metabolomics cuts to the chase to chase the cuts - pp5 - 6
Matthew Bogyo
doi:10.1038/nchembio0109-5
Peptidases are enzymes that trim small protein fragments called peptides to regulate their biological functions. A new method opens the door to chasing down and identifying important cutting events mediated by peptidases involved in metabolic regulation.
Full Text - Metabolomics cuts to the chase to chase the cuts | PDF (1,020 KB) - Metabolomics cuts to the chase to chase the cuts
See also: Brief Communication by Tagore et al.
Engineering fluorination - pp6 - 7
Graham Sandford
doi:10.1038/nchembio0109-6
Cytochrome P450 enzymes selectively oxidize relatively unactivated sites in a range of model drug-like substrates in vitro. The hydroxylated products can be transformed into selectively fluorinated systems, providing a rapid sequential method for the identification, activation and fluorination of saturated sites in drug candidates.
Full Text - Engineering fluorination | PDF (184 KB) - Engineering fluorination
Decoding endocannabinoid signaling - pp8 - 9
Lawrence J Marnett
doi:10.1038/nchembio0109-8
Development of an inhibitor of an endocannabinoid-degrading enzyme provides insights into the role of 2-arachidonoylglycerol in the nervous system.
Full Text - Decoding endocannabinoid signaling | PDF (338 KB) - Decoding endocannabinoid signaling
See also: Article by Long et al.
A road map of cellular protein homeostasis - pp9 - 11
Xiaolu L Ang & J Wade Harper
doi:10.1038/nchembio0109-9
A powerful technology called global protein stability profiling allows rates of protein turnover to be determined for a substantial fraction of the human proteome in a single experiment. This approach sets the stage for systems-level analyses of the dynamics of the mammalian proteome.
Full Text - A road map of cellular protein homeostasis | PDF (343 KB) - A road map of cellular protein homeostasis
Research highlights - pp12 - 13
doi:10.1038/nchembio0109-12
Full Text - Research highlights | PDF (165 KB) - Research highlights
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Review
Amyloid formation by globular proteins under native conditions - pp15 - 22
Fabrizio Chiti & Christopher M Dobson
doi:10.1038/nchembio.131
Abstract - Amyloid formation by globular proteins under native conditions | Full Text - Amyloid formation by globular proteins under native conditions | PDF (996 KB) - Amyloid formation by globular proteins under native conditions
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Brief Communications
Peptidase substrates via global peptide profiling - pp23 - 25
Debarati M Tagore, Whitney M Nolte, John M Neveu, Roberto Rangel, Liliana Guzman-Rojas, Renata Pasqualini, Wadih Arap, William S Lane & Alan Saghatelian
doi:10.1038/nchembio.126
Abstract - Peptidase substrates via global peptide profiling | Full Text - Peptidase substrates via global peptide profiling | PDF (183 KB) - Peptidase substrates via global peptide profiling | Supplementary information | Chemical compounds
See also: News and Views by Bogyo
Chemo-enzymatic fluorination of unactivated organic compounds - pp26 - 28
Andrea Rentmeister, Frances H Arnold & Rudi Fasan
doi:10.1038/nchembio.128
Abstract - Chemo-enzymatic fluorination of unactivated organic compounds | Full Text - Chemo-enzymatic fluorination of unactivated organic compounds | PDF (314 KB) - Chemo-enzymatic fluorination of unactivated organic compounds | Supplementary information | Chemical compounds
See also: News and Views by Sandford
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Top of pageArticles
Substrate selection by the proteasome during degradation of protein complexes - pp29 - 36
Sumit Prakash, Tomonao Inobe, Ace Joseph Hatch & Andreas Matouschek
doi:10.1038/nchembio.130
Abstract - Substrate selection by the proteasome during degradation of protein complexes | Full Text - Substrate selection by the proteasome during degradation of protein complexes | PDF (622 KB) - Substrate selection by the proteasome during degradation of protein complexes | Supplementary information | Chemical compounds
See also: News and Views by Wandless
Selective blockade of 2-arachidonoylglycerol hydrolysis produces cannabinoid behavioral effects - pp37 - 44
Jonathan Z Long, Weiwei Li, Lamont Booker, James J Burston, Steven G Kinsey, Joel E Schlosburg, Franciso J Pavón, Antonia M Serrano, Dana E Selley, Loren H Parsons, Aron H Lichtman & Benjamin F Cravatt
doi:10.1038/nchembio.129
Abstract - Selective blockade of 2-arachidonoylglycerol hydrolysis produces cannabinoid behavioral effects | Full Text - Selective blockade of 2-arachidonoylglycerol hydrolysis produces cannabinoid behavioral effects | PDF (544 KB) - Selective blockade of 2-arachidonoylglycerol hydrolysis produces cannabinoid behavioral effects | Supplementary information | Chemical compounds
See also: News and Views by Marnett
Transport and signaling via the amino acid binding site of the yeast Gap1 amino acid transceptor - pp45 - 52
Griet Van Zeebroeck, Beatriz Monge Bonini, Matthias Versele & Johan M Thevelein
doi:10.1038/nchembio.132
Abstract - Transport and signaling via the amino acid binding site of the yeast Gap1 amino acid transceptor | Full Text - Transport and signaling via the amino acid binding site of the yeast Gap1 amino acid transceptor | PDF (528 KB) - Transport and signaling via the amino acid binding site of the yeast Gap1 amino acid transceptor | Supplementary information
Structural and functional characterization of 2-oxo-histidine in oxidized PerR protein - pp53 - 59
Daouda A K Traoré, Abdelnasser El Ghazouani, Lilian Jacquamet, Franck Borel, Jean-Luc Ferrer, David Lascoux, Jean-Luc Ravanat, Michel Jaquinod, Geneviève Blondin, Christelle Caux-Thang, Victor Duarte & Jean-Marc Latour
doi:10.1038/nchembio.133
Abstract - Structural and functional characterization of 2-oxo-histidine in oxidized PerR protein | Full Text - Structural and functional characterization of 2-oxo-histidine in oxidized PerR protein | PDF (422 KB) - Structural and functional characterization of 2-oxo-histidine in oxidized PerR protein | Supplementary information | Chemical compounds
