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At the crossroad of thiamine degradation and biosynthesis

The physiological significance of thiaminase II has escaped our understanding for many years. The recent discovery of a new thiamine salvage pathway shows that this enzyme is involved in the regeneration of precursors for thiamine biosynthesis.

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Figure 1: Proposed thiamine salvage pathway in Bacillus halodurans.

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Bettendorff, L. At the crossroad of thiamine degradation and biosynthesis. Nat Chem Biol 3, 454–455 (2007). https://doi.org/10.1038/nchembio0807-454

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