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Letter

Nature Chemical Biology 3, 263–267 (1 May 2007) | doi:10.1038/nchembio871

Molecular imaging of hydrogen peroxide produced for cell signaling

Evan W Miller , Orapim Tulyathan , Ehud Y Isacoff & Christopher J Chang

Hydrogen peroxide (H2O2) is emerging as a newly recognized messenger in cellular signal transduction. However, a substantial challenge in elucidating its diverse roles in complex biological environments is the lack of methods for probing this reactive oxygen metabolite in living systems with molecular specificity.