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Understanding DNA-based catalysis one molecule at a time

DNA is the newest member of the enzyme club. The first glimpse of DNAzyme conformational changes at the single-molecule level reveals that enzymes made of DNA can use the same modi operandi as protein and RNA catalysts.

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Figure 1: The secondary structure of 8–17.

References

  1. Breaker, R.R. Science 290, 2095–2096 (2000).

    Article  CAS  Google Scholar 

  2. Achenbach, J.C., Chiuman, W., Cruz, R.P. & Li, Y. Curr. Pharm. Biotechnol. 5, 321–336 (2004).

    Article  CAS  Google Scholar 

  3. Kim, H.-K., Rasnik, I., Liu, J., Ha, T. & Lu, Y. Nat. Chem. Biol. 3, 763–768 (2007).

    Article  CAS  Google Scholar 

  4. Breaker, R.R. & Joyce, G.F. Chem. Biol. 1, 223–229 (1994).

    Article  CAS  Google Scholar 

  5. Kruger, K. et al. Cell 31, 147–157 (1982).

    Article  CAS  Google Scholar 

  6. Guerrier-Takada, C., Gardiner, K., Marsh, T., Pace, N. & Altman, S. Cell 35, 849–857 (1983).

    Article  CAS  Google Scholar 

  7. Santoro, S.W. & Joyce, G.F. Proc. Natl. Acad. Sci. USA 94, 4262–4266 (1997).

    Article  CAS  Google Scholar 

  8. Cruz, R.P.G., Withers, J.W. & Li, Y. Chem. Biol. 11, 57–67 (2004).

    Article  CAS  Google Scholar 

  9. Kim, H.K. et al. J. Am. Chem. Soc. 129, 6896–6902 (2007).

    Article  CAS  Google Scholar 

  10. Nahas, M.K. et al. Nat. Struct. Mol. Biol. 11, 1107–1113 (2004).

    Article  CAS  Google Scholar 

  11. Khvorova, A., Lescoute, A., Westhof, E. & Jayasena, S.D. Nat. Struct. Biol. 10, 708–712 (2003).

    Article  CAS  Google Scholar 

Download references

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Schlosser, K., Li, Y. Understanding DNA-based catalysis one molecule at a time. Nat Chem Biol 3, 753–754 (2007). https://doi.org/10.1038/nchembio1207-753

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