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Letter

Nature Chemical Biology 3, 652–656 (1 October 2007) | doi:10.1038/nchembio.2007.23

A new family of ATP-dependent oligomerization-macrocyclization biocatalysts

Nadia Kadi , Daniel Oves-Costales , Francisco Barona-Gomez & Gregory L Challis

Oligomerization and macrocyclization reactions are key steps in the biosynthesis of many bioactive natural products. Important macrocycles include the antibiotic daptomycin (1; ref.