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June 2006, Volume 2 Number 6 pp283-346

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1st anniversary highlights

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In This Issue

In This Issue

 pv

doi:10.1038/nchembio0606-v

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Editorial

Our paper anniversary

 p283

doi:10.1038/nchembio0606-283

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Commentary

Making carbon-nitrogen bonds in biological and chemical synthesis

 pp284 - 287

Ryan Hili and Andrei K Yudin

doi:10.1038/nchembio0606-284

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Meeting Report

A century at the chemistry-biology interface

 pp288 - 292

Jennifer J Kohler

doi:10.1038/nchembio0606-288

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Elements

Jeremy Knowles

 p293

Joanne Kotz

doi:10.1038/nchembio0606-293

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News and Views

Snapshots of three intermediates at the active site of pyruvate oxidase

 pp294 - 295

Perry A Frey

doi:10.1038/nchembio0606-294

See also: Letter by Wille et al.

Signalomic signatures enlighten drug profiling

 pp295 - 296

Robert T Abraham

doi:10.1038/nchembio0606-295

See also: Article by MacDonald et al.

Nucleation of huntingtin aggregation in cells

 pp297 - 298

Ronald Wetzel

doi:10.1038/nchembio0606-297

See also: Letter by Colby et al.

Wanting contact: how to pick up a channel

 pp298 - 299

Daniel L Minor, Jr

doi:10.1038/nchembio0606-298

See also: Letter by Holden et al.

Chemical knockout of C-reactive protein in cardiovascular disease

 pp300 - 301

Jay W Heinecke

doi:10.1038/nchembio0606-300

Research Highlights

 p303

doi:10.1038/nchembio0606-303

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Review

Modular approaches to expanding the functions of living matter

 pp304 - 311

Jason W Chin

Published online: 18 May 2006 | doi:10.1038/nchembio789

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Brief Communication

Site-specific PEGylation of native disulfide bonds in therapeutic proteins

 pp312 - 313

Sunil Shaunak, Antony Godwin, Ji-Won Choi, Sibu Balan, Elisa Pedone, Damotharan Vijayarangam, Sibylle Heidelberger, Ian Teo, Mire Zloh and Steve Brocchini

Published online: 23 April 2006 | doi:10.1038/nchembio786

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Letters

Direct transfer of membrane proteins from bacteria to planar bilayers for rapid screening by single-channel recording

 pp314 - 318

Matthew A Holden, Lakmal Jayasinghe, Oliver Daltrop, Amy Mason and Hagan Bayley

Published online: 07 May 2006 | doi:10.1038/nchembio793

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Stochastic kinetics of intracellular huntingtin aggregate formation

 pp319 - 323

David W Colby, John P Cassady, Grace C Lin, Vernon M Ingram and K Dane Wittrup

Published online: 14 May 2006 | doi:10.1038/nchembio792

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The catalytic cycle of a thiamin diphosphate enzyme examined by cryocrystallography

 pp324 - 328

Georg Wille, Danilo Meyer, Andrea Steinmetz, Erik Hinze, Ralph Golbik and Kai Tittmann

Published online: 07 May 2006 | doi:10.1038/nchembio788

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Articles

Identifying off-target effects and hidden phenotypes of drugs in human cells

 pp329 - 337

Marnie L MacDonald, Jane Lamerdin, Stephen Owens, Brigitte H Keon, Graham K Bilter, Zhidi Shang, Zhengping Huang, Helen Yu, Jennifer Dias, Tomoe Minami, Stephen W Michnick and John K Westwick

Published online: 07 May 2006 | doi:10.1038/nchembio790

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The nongenotoxic carcinogens naphthalene and para-dichlorobenzene suppress apoptosis in Caenorhabditis elegans

 pp338 - 345

David Kokel, Yehua Li, Jun Qin and Ding Xue

Published online: 14 May 2006 | doi:10.1038/nchembio791

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Erratum

Erratum: Atomic resolution crystallography reveals how changes in pH shape the protein microenvironment

 p346

Artem Y Lyubimov, Paula I Lario, Ibrahim Moustafa and Alice Vrielink

doi:10.1038/nchembio0606-346a

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Corrigendum

Corrigendum: Elevated levels of oxidized cholesterol metabolites in Lewy body disease brains accelerate alpha-synuclein fibrilization

 p346

Daryl A Bosco, Douglas M Fowler, Qinghai Zhang, Jorge Nieva, Evan T Powers, Paul Wentworth, Jr, Richard A Lerner and Jeffery W Kelly

doi:10.1038/nchembio0606-346b


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