In diseases linked to protein aggregation, the initiation of aggregation can be a critical point in the disease mechanism. New studies in cells expressing huntingtin exon I suggest that the initiation of polyglutamine aggregation proceeds by a simple nucleation mechanism.
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References
Colby, D.W., Cassady, J., Lin, G., Ingram, V.M. & Wittrup, K.D. Nat. Chem. Biol. 2, 319–323 (2006).
Chen, S., Ferrone, F. & Wetzel, R. Proc. Natl. Acad. Sci. USA 99, 11884–11889 (2002).
Bhattacharyya, A.M., Thakur, A. & Wetzel, R. Proc. Natl. Acad. Sci. USA 102, 15400–15405 (2005).
Ross, C.A. & Poirier, M.A. Nat. Rev. Mol. Cell Biol. 6, 891–898 (2005).
Arrasate, M., Mitra, S., Schweitzer, E.S., Segal, M.R. & Finkbeiner, S. Nature 431, 805–810 (2004).
Osmand, A.P., Berthelier, V. & Wetzel, R. Methods Enzymol. (in the press).
Wetzel, R. in Genetic Instabilities and Neurological Diseases (eds. Wells, R. & Ashizawa, T.) (Elsevier, San Diego, California, USA, in the press).
Ferrone, F. Methods Enzymol. 309, 256–274 (1999).
Poirier, M.A. et al. J. Biol. Chem. 277, 41032–41037 (2002).
Li, H. et al. Hum. Mol. Genet. 8, 1227–1236 (1999).
Menalled, L.B. et al. J. Neurosci. 22, 8266–8276 (2002).
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Wetzel, R. Nucleation of huntingtin aggregation in cells. Nat Chem Biol 2, 297–298 (2006). https://doi.org/10.1038/nchembio0606-297
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DOI: https://doi.org/10.1038/nchembio0606-297
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