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Lox and Cre sandwich

Nature Chemical Biology volume 1, pages 246–247 (2005)Cite this article

Unlike many site-specific recombinases that require accessory proteins, the Cre recombinase itself organizes a synaptic complex to initiate the recombination reaction. A new study suggests how Cre recombinase accomplishes this catalytic feat.

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Figure 1: The Cre recombination reaction.

References

  1. Rossant, J. & Nagy, A. Nat. Med. 1, 592–594 (1995).

    Article  CAS  Google Scholar 

  2. Ghosh, K., Lau, C.K., Gupta, K. & Van Duyne, G.D. Nat. Chem. Biol. 1, 275–282 (2005).

    Article  CAS  Google Scholar 

  3. Sternberg, N., Hamilton, D., Austin, S., Yarmolinsky, M. & Hoess, R. Cold Spring Harb. Symp. Quant. Biol. 45, 297–309 (1981).

    Article  CAS  Google Scholar 

  4. Nunes-Düby, S.E., Kwon, H.J., Tirumalai, R.S., Ellenberger, T. & Landy, A. Nucleic Acids Res. 26, 391–406 (1998).

    Article  Google Scholar 

  5. Hoess, R., Wierzbicki, A. & Abremski, K. Proc. Natl. Acad. Sci. USA 84, 6840–6844 (1987).

    Article  CAS  Google Scholar 

  6. Lee, L. & Sadowski, P.D. J. Mol. Biol. 326, 397–412 (2003).

    Article  CAS  Google Scholar 

  7. Gopaul, D.N. & Van Duyne, G.D. Curr. Opin. Struct. Biol. 9, 14–20 (1999).

    Article  CAS  Google Scholar 

  8. Ennifar, E., Meyer, J.E., Buchholz, F., Stewart, A.F. & Suck, D. Nucleic Acids Res. 31, 5449–5460 (2003).

    Article  CAS  Google Scholar 

  9. Martin, S.S., Pulido, E., Chu, V.C., Lechner, T.S. & Baldwin, E.P. J. Mol. Biol. 319, 107–127 (2002).

    Article  CAS  Google Scholar 

  10. Guo, F., Gopaul, D.N. & Van Duyne, G.D. Proc. Natl. Acad. Sci. USA 96, 7143–7148 (1999).

    Article  CAS  Google Scholar 

  11. Lee, L. & Sadowski, P.D. in Progress in Nucleic Acid Research and Molecular Biology vol. 80 (Ed. K. Moldave) 1–40 (Elsevier, St. Louis, USA 2005).

    Google Scholar 

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Authors and Affiliations

  1. Department of Molecular and Cell Biology, University of California Berkeley, Berkeley, 94720-3202, California

    Linda Lee

  2. Department of Molecular and Medical Genetics, University of Toronto, Toronto, M5S 1A8, Ontario, Canada

    Paul D Sadowski

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  1. Linda Lee
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  2. Paul D Sadowski
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Lee, L., Sadowski, P. Lox and Cre sandwich. Nat Chem Biol 1, 246–247 (2005). https://doi.org/10.1038/nchembio1005-246

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