In This Issue - p120
doi:10.1038/nchembio0805-120
Table of contents
August 2005, Volume 1 No 3 pp120-173
About the coverTop of page
Editorial
An emerging role for chemical biology - p121
doi:10.1038/nchembio0805-121
Full Text - An emerging role for chemical biology | PDF (77 KB) - An emerging role for chemical biology
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Commentary
Natural insights for chemical biologists - pp122 - 124
Christopher T Walsh
doi:10.1038/nchembio0805-122
Chemical biologists studying natural-product pathways encoded in genomes have unearthed new chemistry and insights into the evolution of biologically active metabolites.
Full Text - Natural insights for chemical biologists | PDF (150 KB) - Natural insights for chemical biologists
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News and Views
New screening tools for lead compound identification - p125
Tomi K Sawyer
doi:10.1038/nchembio0805-125
The identification of promising lead compounds from high-throughput screens is still a very complex problem. A new high-throughput assay for identifying aggregation-based false positives could help.
Full Text - New screening tools for lead compound identification | PDF (113 KB) - New screening tools for lead compound identification
See also: Letter by Feng et al.
Controlled S-nitrosation - pp126 - 127
Steven R Tannenbaum & Ji-Eun Kim
doi:10.1038/nchembio0805-126
Protein nitrosation is an important signaling mechanism in vivo; however, mechanisms for selective nitric oxide modification of cysteines have not been described. Thioredoxin is now shown to rapidly and site-specifically catalyze S-nitrosation of an active site cysteine of caspase-3.
Full Text - Controlled S-nitrosation | PDF (158 KB) - Controlled S-nitrosation
See also: Letter by Mitchell & Marletta
Getting the iron out - pp127 - 128
Clifton E. Barry, III & Helena Boshoff
doi:10.1038/nchembio0805-127
In the competition for control of iron between Mycobacterium tuberculosis and host cells, very little is understood about how these bacteria use small-molecule siderophores to obtain iron. A mechanism is now shown for intracellular iron acquisition by mycobacterial lipophilic siderophores.
Full Text - Getting the iron out | PDF (126 KB) - Getting the iron out
See also: Letter by Luo et al.
Research Highlights - p129
doi:10.1038/nchembio0805-129
Full Text - Research Highlights | PDF (77 KB) - Research Highlights
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Review
Assignment of protein function in the postgenomic era - pp130 - 142
Alan Saghatelian & Benjamin F Cravatt
doi:10.1038/nchembio0805-130
Abstract - Assignment of protein function in the postgenomic era | Full Text - Assignment of protein function in the postgenomic era | PDF (646 KB) - Assignment of protein function in the postgenomic era
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Brief Communication
Identification of a specific inhibitor of the histone methyltransferase SU(VAR)3-9 - pp143 - 145
Dorothea Greiner, Tiziana Bonaldi, Ragnhild Eskeland, Ernst Roemer & Axel Imhof
doi:10.1038/nchembio721
Abstract - Identification of a specific inhibitor of the histone methyltransferase SU(VAR)3-9 | Full Text - Identification of a specific inhibitor of the histone methyltransferase SU(VAR)3-9 | PDF (179 KB) - Identification of a specific inhibitor of the histone methyltransferase SU(VAR)3-9 | Supplementary information | Chemical compounds
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Letters
High-throughput assays for promiscuous inhibitors - pp146 - 148
Brian Y Feng, Anang Shelat, Thompson N Doman, R Kip Guy & Brian K Shoichet
doi:10.1038/nchembio718
First Paragraph - High-throughput assays for promiscuous inhibitors | Full Text - High-throughput assays for promiscuous inhibitors | PDF (229 KB) - High-throughput assays for promiscuous inhibitors | Supplementary information | Chemical compounds
See also: News and Views by Sawyer
Mycobactin-mediated iron acquisition within macrophages - pp149 - 153
Minkui Luo, Evgeny A Fadeev & John T Groves
doi:10.1038/nchembio717
First Paragraph - Mycobactin-mediated iron acquisition within macrophages | Full Text - Mycobactin-mediated iron acquisition within macrophages | PDF (308 KB) - Mycobactin-mediated iron acquisition within macrophages | Supplementary information | Chemical compounds
See also: News and Views by Barry & Boshoff
Thioredoxin catalyzes the S-nitrosation of the caspase-3 active site cysteine - pp154 - 158
Douglas A Mitchell & Michael A Marletta
doi:10.1038/nchembio720
First Paragraph - Thioredoxin catalyzes the S-nitrosation of the caspase-3 active site cysteine | Full Text - Thioredoxin catalyzes the S-nitrosation of the caspase-3 active site cysteine | PDF (235 KB) - Thioredoxin catalyzes the S-nitrosation of the caspase-3 active site cysteine | Supplementary information
See also: News and Views by Tannenbaum & Kim
Top of pageA network of orthogonal ribosome
Top of pageArticles
A network of orthogonal ribosome
mRNA pairs - pp159 - 166
Oliver Rackham & Jason W Chin
doi:10.1038/nchembio719
Abstract - A network of orthogonal ribosome[middot]mRNA pairs | Full Text - A network of orthogonal ribosomemRNA pairs | PDF (548 KB) - A network of orthogonal ribosomemRNA pairs | Supplementary information
Small-molecule interaction with a five-guanine-tract G-quadruplex structure from the human MYC promoter - pp167 - 173
Anh Tuân Phan, Vitaly Kuryavyi, Hai Yan Gaw & Dinshaw J Patel
doi:10.1038/nchembio723
Abstract - Small-molecule interaction with a five-guanine-tract G-quadruplex structure from the human : MYC: promoter | Full Text - Small-molecule interaction with a five-guanine-tract G-quadruplex structure from the human MYC promoter | PDF (738 KB) - Small-molecule interaction with a five-guanine-tract G-quadruplex structure from the human MYC promoter | Supplementary information | Chemical compounds
