Identification of endogenous glycan-binding ligands for cell-surface receptors has been difficult. Incorporation of a photoactive sialic acid analog into B-cell surface glycoproteins suggests that CD22 molecules may cluster by binding carbohydrate antigens on neighboring CD22 molecules.
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Yarema, K., Sun, Z. A photochemical snapshot of CD22 binding. Nat Chem Biol 1, 69–70 (2005). https://doi.org/10.1038/nchembio0705-69
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DOI: https://doi.org/10.1038/nchembio0705-69
