Oxidation of 5-methylcytosine has been proposed to mediate active and passive DNA demethylation. Tracking the history of DNA modifications has now provided the first solid evidence that 5-hydroxymethylcytosine is a stable epigenetic modification.
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Brazauskas, P., Kriaucionis, S. Another stable base in DNA. Nature Chem 6, 1031–1033 (2014). https://doi.org/10.1038/nchem.2115
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DOI: https://doi.org/10.1038/nchem.2115