Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Drug discovery

Combichem all over again

The generation of chemical libraries for screening is a key part of the drug discovery process. Now, two studies describe attempts to combine features of natural product biosynthesis into the creation of libraries with the aim of mimicking nature's success at the production of bioactive molecules.

This is a preview of subscription content, access via your institution

Access options

Rent or buy this article

Prices vary by article type

from$1.95

to$39.95

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Contemporary approaches to combinatorial chemistry.

References

  1. Mullin, R. Chem. Eng. News 82, 23–32 (2004).

    Google Scholar 

  2. Smith, G. P. & Petrenko, V. A. Chem. Rev. 97, 391–410 (1997).

    Article  CAS  Google Scholar 

  3. Takahashi, T. T., Austin, R. J. & Roberts, R. W. Trends Biochem. Sci. 28, 159–165 (2003).

    Article  CAS  Google Scholar 

  4. Josephson, K., Ricardo, A. & Szostak, J. W. Drug. Discov. Today 19, 388–399 (2014).

    Article  CAS  Google Scholar 

  5. Franzani, R. M., Neri, D. & Scheuermann, J. Acc. Chem. Res. 47, 1247–1255 (2014).

    Article  Google Scholar 

  6. Clark, M. A. et al. Nature Chem. Biol. 5, 647–654 (2009).

    Article  CAS  Google Scholar 

  7. Huang, Y.-L. & Bode, J. W. Nature Chem. 6, 877–884 10.1038/nchem.2048(2014).

    Article  CAS  Google Scholar 

  8. Carrillo, N., Davalos, E. A., Russak, J. A. & Bode, J. W. J. Am Chem. Soc. 128, 1452–1453 (2006).

    Article  CAS  Google Scholar 

  9. Karageorgis, G., Warriner, S. & Nelson, A. Nature Chem. 6, 872–876 10.1038/nchem.2034(2014).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Derek B. Lowe.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Lowe, D. Combichem all over again. Nature Chem 6, 851–852 (2014). https://doi.org/10.1038/nchem.2074

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nchem.2074

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing