Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Biosynthesis

Not just passing through

Identifying the genes responsible for each step of a natural product biosynthesis has allowed the synthesis to be 'hijacked' to make bioactive compounds, and reveals that some suspected transporter enzymes could have other important roles in fungal defence systems.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: The biosynthesis of pyripyropene A and some related bioactive compounds.

References

  1. Clardy, J. & Walsh, C. T. Nature 432, 829–837 (2004).

    Article  CAS  Google Scholar 

  2. Itoh, T. et al. Nature Chem. 2, 858–864 10.1038/nchem.764(2010).

    Article  CAS  Google Scholar 

  3. Omura, S., Tomoda, H., Kim, Y. K. & Nishida, H. J. Antibiot. 46, 1168–1169 (1993).

    Article  CAS  Google Scholar 

  4. Nierman, W. C. et al. Nature 438, 1151–1156 (2005).

    Article  CAS  Google Scholar 

  5. Ma, S. M. et al. Science 326, 589–592 (2009).

    Article  CAS  Google Scholar 

  6. Crawford, J. M. et al. Nature 461, 1139–1143 (2009).

    Article  CAS  Google Scholar 

  7. Machida, M. et al. Nature 438, 1157–1161 (2005).

    Article  Google Scholar 

  8. www.sbg.bio.ic.ac.uk/phyre/

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Jon Clardy.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Crawford, J., Clardy, J. Not just passing through. Nature Chem 2, 805–807 (2010). https://doi.org/10.1038/nchem.848

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nchem.848

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing