Perspectives in 2022

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  • Hydrogen, which possesses the highest gravimetric energy density of any energy carrier, is attractive for both mobile and stationary power, but its low volumetric energy density poses major storage and transport challenges. This Perspective delineates potential use cases and defines the challenges facing the development of materials for efficient hydrogen storage.

    • Mark D. Allendorf
    • Vitalie Stavila
    • Tom Autrey
    Perspective
  • Droplet interface bilayers (DIBs) are a type of artificial bilayer that can act as cell membrane mimics. This Perspective surveys how DIBs can be used to mimic key cellular features (such as bilayer asymmetry) and processes (such as drug movement), and discusses challenges that need to be overcome to enable DIBs to reach their full potential as biomimetic model membranes.

    • Elanna B. Stephenson
    • Jaime L. Korner
    • Katherine S. Elvira
    Perspective
  • A substantial proportion of the data generated in chemistry research is captured non-digitally and reported in ways that non-accessible to both humans and computers. A variety of tools do exist to capture, analyse and publish data in an open, reusable, machine-actionable manner — they should be connected to create an open-science platform for chemistry.

    • Kevin Maik Jablonka
    • Luc Patiny
    • Berend Smit
    Perspective
  • DNA-encoded libraries can be applied in a diverse range of applications beyond simple binding assays. This Perspective covers the recent progress in using DNA-encoded chemical libraries to investigate complex biological targets and discusses their potential to identify structures that elicit function or possess other useful properties.

    • Yiran Huang
    • Yizhou Li
    • Xiaoyu Li
    Perspective