A collage of Nature Cell Biology covers from the past decade.

Suppression of KLF17 expression in NMuMG cells increases expression of the mesenchymal marker vimentin (green) and induces epithelial–mesenchymal transition.article p1297

The planar cell polarity effector Fuz regulates membrane trafficking to cilia in Xenopus (the image shows a scanning electron micrograph of wild-type epidermis) and in mouse.letter p1225

Multivesicular bodies are associated with components of the RNA-induced silencing complex (RISC) and factors involved in protein sorting to multivesicular bodies are important for miRNA-mediated gene silencing.letter p1143

Persistent DNA damage signalling (red) correlates with high levels of the inflammatory cytokine IL-6 (green) in invasive ductal carcinoma of the breast.letter p973

A 3D image of inflammatory breast cancer tumour cell emboli that form tight spherical non-adherent clusters responsible for highly efficient passive metastasis.p903

The U3 snoRNP component Wicked, which is required for pre-ribosomal RNA maturation (green), is localized asymmetrically in dividing Drosophila germline cells (DNA in red) and is critical for stem cell self-renewal.article p685

Bone morphogenetic protein (BMP) heterodimers trigger the assembly of heterodimeric receptors to direct dorsoventral axis determination (shown here as a gradient of BMP effectors, phospho-Smad1/5, in green)[letter p637]

p53-cofactor JMY nucleates actin filaments in cells. Expression of the actin nucleation region of JMY in U2OS cells induces the formation of actin filaments (phalloidin, red).letter p451

Prions spread between cells through tunnelling nanotubes.letter p328

A 3D projection of the anchor cell in C. elegans (magenta) as it invades through the basement membrane (green) and into the vulval epithelium. The UNC-6 (netrin) pathway polarizes the anchor cell and orients it for invasion.p 183

In the developing root epidermis of Arabidopsis thaliana, auxin hormone is delivered to root hair cells (red) by non-hair cells expressing the auxin influx carrier AUX1 (yellow), to sustain root hair differentiation.

[letter p78]