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Focus

Focus on Development and Disease

Much progress has been made in our understanding of the molecular mechanisms underlying animal development, uncovering numerous links with human disease pathologies.

This issue of Nature Cell Biology presents a series of specially-commissioned articles that highlights how developmental pathways gone awry can cause disease. These articles are available free until the end of February 2008.

The focus is sponsored by the March of Dimes foundation, as well as the Institute of Biochemistry and Cell Biology, Shanghai, and the Guangzhou Institute of Biomedicine and Health of the Chinese Academy of Sciences.

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Editorial

Focus on Development and Disease

Developing disease p983

doi:10.1038/ncb0907-983


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Commentaries

Focus on Development and Disease

Human–animal cytoplasmic hybrid embryos, mitochondria, and an energetic debate pp988 - 992

Justin St John & Robin Lovell-Badge

doi:10.1038/ncb436


Focus on Development and Disease

The mouse ascending: perspectives for human-disease models pp993 - 999

Nadia Rosenthal & Steve Brown

doi:10.1038/ncb437


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Perspectives

Focus on Development and Disease

Differentiation plasticity regulated by TGF-beta family proteins in development and disease pp1000 - 1004

Rik Derynck & Rosemary J. Akhurst

doi:10.1038/ncb434


Focus on Development and Disease

Patching the gaps in Hedgehog signalling pp1005 - 1009

Rajat Rohatgi & Matthew P. Scott

doi:10.1038/ncb435


Focus on Development and Disease

Convergent extension and the hexahedral cell pp1010 - 1015

Jeremy B. A. Green & Lance A. Davidson

doi:10.1038/ncb438


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Review

Focus on Development and Disease

Cell polarity in development and cancer pp1016 - 1024

Andreas Wodarz & Inke Näthke

doi:10.1038/ncb433


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Book Review

Found in translation p1026

Martin Holcik reviews Translational Control in Biology and Medicine by Michael B. Mathews, Nahum Sonenberg & John W. B. Hershey

doi:10.1038/ncb0907-1026


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News and Views

PARtners for endocytosis pp1027 - 1029

Frédéric Wissler & Michel Labouesse

doi:10.1038/ncb0907-1027


Turning to the cold pp1029 - 1031

Victor Sourjik & Ned S. Wingreen

doi:10.1038/ncb0907-1029


Neural stem cells: guardians of the brain pp1031 - 1034

Gianvito Martino & Stefano Pluchino

doi:10.1038/ncb0907-1031


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Articles

S-nitrosylation of microtubule-associated protein 1B mediates nitric-oxide-induced axon retraction pp1035 - 1045

Heike Stroissnigg, Alz caronbeta Tranc caroníková, Luise Descovich, Jakob Fuhrmann, Waltraud Kutschera, Julius Kostan, Arabella Meixner, Fatiha Nothias & Friedrich Propst

doi:10.1038/ncb1625


Focal adhesion kinase controls actin assembly via a FERM-mediated interaction with the Arp2/3 complex pp1046 - 1056

Bryan Serrels, Alan Serrels, Valerie G. Brunton, Mark Holt, Gordon W. McLean, Christopher H. Gray, Gareth E. Jones & Margaret C. Frame

doi:10.1038/ncb1626


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Letters

Correlated three-dimensional light and electron microscopy reveals transformation of mitochondria during apoptosis pp1057 - 1065

Mei G. Sun, James Williams, Cristina Munoz-Pinedo, Guy A. Perkins, Joshua M. Brown, Mark H. Ellisman, Douglas R. Green & Terrence G. Frey

doi:10.1038/ncb1630




Toll-like receptors modulate adult hippocampal neurogenesis pp1081 - 1088

Asya Rolls, Ravid Shechter, Anat London, Yaniv Ziv, Ayal Ronen, Rinat Levy & Michal Schwartz

doi:10.1038/ncb1629

See also: News and Views by Martino & Pluchino


The lipid droplet is an important organelle for hepatitis C virus production pp1089 - 1097

Yusuke Miyanari, Kimie Atsuzawa, Nobuteru Usuda, Koichi Watashi, Takayuki Hishiki, Margarita Zayas, Ralf Bartenschlager, Takaji Wakita, Makoto Hijikata & Kunitada Shimotohno

doi:10.1038/ncb1631


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