Table of contents
January 2006, Volume 8 No 1 pp1-100
About the coverBook Review
Moving from the dish to the fish - p2
Adam Cliffe & Pernille Rørth review Cell Migration in Development and Disease by Doris Wedlich
doi:10.1038/ncb0106-2
Full Text - Moving from the dish to the fish | PDF (113 KB) - Moving from the dish to the fish
Meeting Report
In and around the nucleus - pp3 - 6
Asifa Akhtar & A. Gregory Matera
doi:10.1038/ncb0106-3
Studies of how the eukaryotic nucleus is functionally organized have led to the realization that nuclei are incredibly dynamic. Many nuclear structures are actually by products of a large steady-state flux of macromolecules through a given domain. A recent conference in the south of France on Nuclear Structure and Dynamics brought together scientists with diverse perspectives on the nucleus to try to provide a more coherent picture of the nucleus's dynamic organization and how this architecture is entwined with epigenetic control of gene expression.
Full Text - In and around the nucleus | PDF (665 KB) - In and around the nucleus
News and Views
Ephrins make eyes with planar cell polarity - pp7 - 8
Alexei Poliakov & David G. Wilkinson
doi:10.1038/ncb0106-7
Interactions between Eph receptors and ephrins can restrict or enable the movement of cells by promoting cell repulsion or invasion. Ephrins have now been shown to regulate cell migration by interacting with the planar cell polarity (PCP) pathway.
Full Text - Ephrins make eyes with planar cell polarity | PDF (158 KB) - Ephrins make eyes with planar cell polarity
See also: Letter by Lee et al.
Chromatin and DNA repair: the benefits of relaxation - pp9 - 10
Michael Downey & Daniel Durocher
doi:10.1038/ncb0106-9
DNA is tightly wrapped around histones to form chromatin. How DNA repair molecules interact with this chromatin structure is an emerging question. New findings suggest that chromatin structure impedes the access of DNA repair proteins to sites of DNA damage, thus establishing a mechanism for the function of chromatin remodelling complexes during DNA repair.
Full Text - Chromatin and DNA repair: the benefits of relaxation | PDF (162 KB) - Chromatin and DNA repair: the benefits of relaxation
See also: Letter by Murr et al.
Cdk5 checks p27kip1 in neuronal migration - pp11 - 13
Orly Reiner & Tamar Sapir
doi:10.1038/ncb0106-11
p27kip1, once confined to control of the cell cycle, has more recently been identified as a key regulator of cell migration. In neuronal cells, this function of p27kip1 is regulated by Cdk5.
Full Text - Cdk5 checks p27kip1 in neuronal migration | PDF (227 KB) - Cdk5 checks p27kip1 in neuronal migration
See also: Article by Kawauchi et al.
A SAGA of proteasomal ATPases - p13
Sowmya Swaminathan
doi:10.1038/ncb0106-13
Full Text - A SAGA of proteasomal ATPases | PDF (162 KB) - A SAGA of proteasomal ATPases
A blossoming romance: gamete interactions in flowering plants - pp14 - 16
David Twell
doi:10.1038/ncb0106-14
Since the discovery of double fertilization over a century ago, proteins mediating gamete interactions in flowering plants have remained elusive. A lily protein located at the sperm-cell surface that is required for fertilization offers new hope in understanding this crucial process.
Full Text - A blossoming romance: gamete interactions in flowering plants | PDF (426 KB) - A blossoming romance: gamete interactions in flowering plants
See also: Letter by Mori et al.
Articles
Cdk5 phosphorylates and stabilizes p27kip1 contributing to actin organization and cortical neuronal migration - pp17 - 26
Takeshi Kawauchi, Kaori Chihama, Yo-ichi Nabeshima & Mikio Hoshino
doi:10.1038/ncb1338
Abstract - | Full Text - Cdk5 phosphorylates and stabilizes p27kip1 contributing to actin organization and cortical neuronal migration | PDF (2,608 KB) - Cdk5 phosphorylates and stabilizes p27kip1 contributing to actin organization and cortical neuronal migration | Supplementary information
The tumour-suppressor genes NF2/Merlin and Expanded act through Hippo signalling to regulate cell proliferation and apoptosis - pp27 - 36
Fisun Hamaratoglu, Maria Willecke, Madhuri Kango-Singh, Riitta Nolo, Eric Hyun, Chunyao Tao, Hamed Jafar-Nejad & Georg Halder
doi:10.1038/ncb1339
Abstract - | Full Text - The tumour-suppressor genes NF2/Merlin and Expanded act through Hippo signalling to regulate cell proliferation and apoptosis | PDF (3,095 KB) - The tumour-suppressor genes NF2/Merlin and Expanded act through Hippo signalling to regulate cell proliferation and apoptosis | Supplementary information
ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks - pp37 - 45
Ali Jazayeri, Jacob Falck, Claudia Lukas, Jiri Bartek, Graeme C. M. Smith, Jiri Lukas & Stephen P. Jackson
doi:10.1038/ncb1337
Abstract - | Full Text - ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks | PDF (1,842 KB) - ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks | Supplementary information
Letters
Flotillin-1 defines a clathrin-independent endocytic pathway in mammalian cells - pp46 - 54
Oleg O. Glebov, Nicholas A. Bright & Benjamin J. Nichols
doi:10.1038/ncb1342
First Paragraph - | Full Text - Flotillin-1 defines a clathrin-independent endocytic pathway in mammalian cells | PDF (1,606 KB) - Flotillin-1 defines a clathrin-independent endocytic pathway in mammalian cells | Supplementary information
Dishevelled mediates ephrinB1 signalling in the eye field through the planar cell polarity pathway - pp55 - 63
Hyun-Shik Lee, Yong-Sik Bong, Kathryn B. Moore, Kathleen Soria, Sally A. Moody & Ira O. Daar
doi:10.1038/ncb1344
First Paragraph - | Full Text - Dishevelled mediates ephrinB1 signalling in the eye field through the planar cell polarity pathway | PDF (2,155 KB) - Dishevelled mediates ephrinB1 signalling in the eye field through the planar cell polarity pathway | Supplementary information
GENERATIVE CELL SPECIFIC 1 is essential for angiosperm fertilization - pp64 - 71
Toshiyuki Mori, Haruko Kuroiwa, Tetsuya Higashiyama & Tsuneyoshi Kuroiwa
doi:10.1038/ncb1345
First Paragraph - | Full Text - GENERATIVE CELL SPECIFIC 1 is essential for angiosperm fertilization | PDF (4,697 KB) - GENERATIVE CELL SPECIFIC 1 is essential for angiosperm fertilization
In situ trapping of activated initiator caspases reveals a role for caspase-2 in heat shock-induced apoptosis - pp72 - 77
Shine Tu, Gavin P. McStay, Louis-Martin Boucher, Tak Mak, Helen M. Beere & Douglas R. Green
doi:10.1038/ncb1340
First Paragraph - | Full Text - In situ trapping of activated initiator caspases reveals a role for caspase-2 in heat shock-induced apoptosis | PDF (575 KB) - In situ trapping of activated initiator caspases reveals a role for caspase-2 in heat shock-induced apoptosis | Supplementary information
The Ipl1-Aurora protein kinase activates the spindle checkpoint by creating unattached kinetochores - pp78 - 83
Benjamin A. Pinsky, Charles Kung, Kevan M. Shokat & Sue Biggins
doi:10.1038/ncb1341
First Paragraph - | Full Text - The Ipl1-Aurora protein kinase activates the spindle checkpoint by creating unattached kinetochores | PDF (637 KB) - The Ipl1-Aurora protein kinase activates the spindle checkpoint by creating unattached kinetochores | Supplementary information
PCNA functions as a molecular platform to trigger Cdt1 destruction and prevent re-replication - pp84 - 90
Emily E. Arias & Johannes C. Walter
doi:10.1038/ncb1346
First Paragraph - | Full Text - PCNA functions as a molecular platform to trigger Cdt1 destruction and prevent re-replication | PDF (1,692 KB) - PCNA functions as a molecular platform to trigger Cdt1 destruction and prevent re-replication | Supplementary information
Histone acetylation by Trrap–Tip60 modulates loading of repair proteins and repair of DNA double-strand breaks - pp91 - 99
Rabih Murr, Joanna I. Loizou, Yun-Gui Yang, Cyrille Cuenin, Hai Li, Zhao-Qi Wang & Zdenko Herceg
doi:10.1038/ncb1343
First Paragraph - | Full Text - Histone acetylation by Trrap–Tip60 modulates loading of repair proteins and repair of DNA double-strand breaks | PDF (1,134 KB) - Histone acetylation by Trrap–Tip60 modulates loading of repair proteins and repair of DNA double-strand breaks | Supplementary information
