Journal transfer made easy - p1

doi:10.1038/ncb0105-1a

Full Text - Journal transfer made easy | PDF (84 KB) - Journal transfer made easy

The ultimate search engine? - p1

doi:10.1038/ncb0105-1b

Full Text - The ultimate search engine? | PDF (84 KB) - The ultimate search engine?

Cyclin E at the centre of an identity crisis - pp3 - 5

William Chia & Sergei N. Prokopenko

doi:10.1038/ncb0105-3

Some Drosophila neural progenitor cells generate segment-specific lineages in the thorax versus the abdomen. The basis for these differences is the differential expression of Cyclin E. Cyclin E functions downstream of the homeotic genes and largely independently of its role in proliferation to autonomously specify thoracic identity.

Full Text - Cyclin E at the centre of an identity crisis | PDF (136 KB) - Cyclin E at the centre of an identity crisis

See also: Letter by Berger et al.

CLASP fluxes its mitotic muscles - pp5 - 7

Claire E. Walczak

doi:10.1038/ncb0105-5

Accurate chromosome segregation occurs during each cell division and is orchestrated by the dynamic microtubules of the mitotic spindle. Our understanding of this process has increased severalfold with the elucidation of the molecular components that coordinate microtubule flux.

Full Text - CLASP fluxes its mitotic muscles | PDF (209 KB) - CLASP fluxes its mitotic muscles

See also: Letter by Maiato et al.

A phosphatase for cofilin to be HAD - pp8 - 9

O'Neil Wiggan, Barbara W. Bernstein & James R. Bamburg

doi:10.1038/ncb0105-8

Regulating actin dynamics through cofilin dephosphorylation is the role of a newly identified phosphatase, chronophin, a member of the haloacid dehalogenase (HAD) superfamily. Chronophin, the second cofilin phosphatase to be identified, has high phosphoprotein specificity towards cofilin, but curiously it was also discovered independently as a pyridoxal phosphate (vitamin B6) phosphatase.

Full Text - A phosphatase for cofilin to be HAD | PDF (155 KB) - A phosphatase for cofilin to be HAD

See also: Article by Gohla et al.

Nuclear pore complexes: Round the bend? - pp10 - 12

Wolfram Antonin & Iain W. Mattaj

doi:10.1038/ncb0105-10

Nuclear pore complexes intuitively seem functionally analogous to transmembrane channels. Recent bioinformatic analysis, however, suggests a quite different evolutionary relationship: one between nuclear pore complexes and vesicle coat components. This has led to the provocative hypothesis that these distinct structures share a common role in bending membranes.

Full Text - Nuclear pore complexes: Round the bend? | PDF (222 KB) - Nuclear pore complexes: Round the bend?

Ub in charge: Regulating E2 enzyme nuclear import - pp12 - 14

Xiang-Dong Zhang & Michael J Matunis

doi:10.1038/ncb0105-12

The activation and targeted localization of ubiquitin E2 conjugating enzymes could provide a point for regulating ubiquitin-dependent cell functions. Supporting this view, the ubiquitin charging and activation of a class of E2 enzymes has been directly linked to their nuclear import.

Full Text - Ub in charge: Regulating E2 enzyme nuclear import | PDF (153 KB) - Ub in charge: Regulating E2 enzyme nuclear import

Hearing the messenger: Ins(1,4,5)P₃ and deafness - pp14 - 16

Roberto Bruzzone & Martine Cohen-Salmon

doi:10.1038/ncb0105-14

Genetic studies have conclusively linked connexin channels to human diseases, but the nature of the signals that are disrupted by channel mutations has remained elusive. A recent study has taken advantage of a deafness-causing mutation to suggest that permeability to inositol trisphosphate, the Ca²⁺-mobilizing messenger, is crucial for normal hearing.

Full Text - Hearing the messenger: Ins(1,4,5)P3 and deafness | PDF (315 KB) - Hearing the messenger: Ins(1,4,5)P3 and deafness

See also: Letter by Beltramello et al.

Wnt muscles up to CREB - p16

Myrto Raftopoulou

doi:10.1038/ncb0105-16

Full Text - Wnt muscles up to CREB | PDF (145 KB) - Wnt muscles up to CREB

Yasutomi Nishizuka 1932–2004 - p17

Robert Michell

doi:10.1038/ncb0105-17

Full Text - Yasutomi Nishizuka 1932–2004 | PDF (128 KB) - Yasutomi Nishizuka 1932–2004

A stern view of gastrulation - p19

Irinka Castanon-Ortega & Carl-Philipp Heisenberg review Gastrulation: From Cells to Embryo by Claudio Stern

doi:10.1038/ncb0105-19

Full Text - A stern view of gastrulation | PDF (90 KB) - A stern view of gastrulation

Chronophin, a novel HAD-type serine protein phosphatase, regulates cofilin-dependent actin dynamics - pp21 - 29

Antje Gohla, Jörg Birkenfeld & Gary M. Bokoch

doi:10.1038/ncb1201

Abstract - | Full Text - Chronophin, a novel HAD-type serine protein phosphatase, regulates cofilin-dependent actin dynamics | PDF (2,477 KB) - Chronophin, a novel HAD-type serine protein phosphatase, regulates cofilin-dependent actin dynamics | Supplementary information

See also: News and Views by Wiggan et al.

Akt and 14-3-3 regulate Miz1 to control cell-cycle arrest after DNA damage - pp30 - 41

Michael Wanzel, Daniela Kleine-Kohlbrecher, Steffi Herold, Andreas Hock, Katrien Berns, Jongsun Park, Brian Hemmings & Martin Eilers

doi:10.1038/ncb1202

Abstract - | Full Text - Akt and 14-3-3 regulate Miz1 to control cell-cycle arrest after DNA damage | PDF (1,176 KB) - Akt and 14-3-3 regulate Miz1 to control cell-cycle arrest after DNA damage | Supplementary information

Drosophila CLASP is required for the incorporation of microtubule subunits into fluxing kinetochore fibres - pp42 - 47

Helder Maiato, Alexey Khodjakov & Conly L. Rieder

doi:10.1038/ncb1207

First Paragraph - | Full Text - Drosophila CLASP is required for the incorporation of microtubule subunits into fluxing kinetochore fibres | PDF (721 KB) - Drosophila CLASP is required for the incorporation of microtubule subunits into fluxing kinetochore fibres | Supplementary information

See also: News and Views by Walczak

Coupling of ER exit to microtubules through direct interaction of COPII with dynactin - pp48 - 55

Peter Watson, Rebecca Forster, Krysten J. Palmer, Rainer Pepperkok & David J. Stephens

doi:10.1038/ncb1206

First Paragraph - | Full Text - Coupling of ER exit to microtubules through direct interaction of COPII with dynactin | PDF (1,334 KB) - Coupling of ER exit to microtubules through direct interaction of COPII with dynactin | Supplementary information

A critical role for Cyclin E in cell fate determination in the central nervous system of Drosophila melanogaster - pp56 - 62

Christian Berger, S. K. Pallavi, Mohit Prasad, L. S. Shashidhara & Gerhard M. Technau

doi:10.1038/ncb1203

First Paragraph - | Full Text - A critical role for Cyclin E in cell fate determination in the central nervous system of Drosophila melanogaster | PDF (2,604 KB) - A critical role for Cyclin E in cell fate determination in the central nervous system of Drosophila melanogaster | Supplementary information

See also: News and Views by Chia & Prokopenko

Impaired permeability to Ins(1,4,5)P₃ in a mutant connexin underlies recessive hereditary deafness - pp63 - 69

Martina Beltramello, Valeria Piazza, Feliksas F. Bukauskas, Tullio Pozzan & Fabio Mammano

doi:10.1038/ncb1205

First Paragraph - | Full Text - Impaired permeability to Ins(1,4,5)P3 in a mutant connexin underlies recessive hereditary deafness | PDF (1,234 KB) - Impaired permeability to Ins(1,4,5)P3 in a mutant connexin underlies recessive hereditary deafness | Supplementary information

See also: News and Views by Bruzzone & Cohen-Salmon

IAPs are functionally non-equivalent and regulate effector caspases through distinct mechanisms - pp70 - 77

Tencho Tenev, Anna Zachariou, Rebecca Wilson, Mark Ditzel & Pascal Meier

doi:10.1038/ncb1204

First Paragraph - | Full Text - IAPs are functionally non-equivalent and regulate effector caspases through distinct mechanisms | PDF (1,344 KB) - IAPs are functionally non-equivalent and regulate effector caspases through distinct mechanisms | Supplementary information

Negative regulation of EGFR signalling through integrin-₁₁-mediated activation of protein tyrosine phosphatase TCPTP - pp78 - 85

Elina Mattila, Teijo Pellinen, Jonna Nevo, Karoliina Vuoriluoto, Antti Arjonen & Johanna Ivaska

doi:10.1038/ncb1209

First Paragraph - | Full Text - Negative regulation of EGFR signalling through integrin-11-mediated activation of protein tyrosine phosphatase TCPTP | PDF (922 KB) - Negative regulation of EGFR signalling through integrin-11-mediated activation of protein tyrosine phosphatase TCPTP | Supplementary information

Drosophila Smoothened phosphorylation sites essential for Hedgehog signal transduction - pp86 - 92

Sergey Apionishev, Natalya M. Katanayeva, Steven A. Marks, Daniel Kalderon & Andrew Tomlinson

doi:10.1038/ncb1210

First Paragraph - | Full Text - Drosophila Smoothened phosphorylation sites essential for Hedgehog signal transduction | PDF (2,253 KB) - Drosophila Smoothened phosphorylation sites essential for Hedgehog signal transduction | Supplementary information

The human mitotic checkpoint protein BubR1 regulates chromosome–spindle attachments - pp93 - 98

Michael A. Lampson & Tarun M. Kapoor

doi:10.1038/ncb1208

First Paragraph - | Full Text - The human mitotic checkpoint protein BubR1 regulates chromosome–spindle attachments | PDF (1,194 KB) - The human mitotic checkpoint protein BubR1 regulates chromosome–spindle attachments | Supplementary information