The end of the beginning? - pE185

doi:10.1038/ncb0802-e185

Full Text - The end of the beginning? | PDF (59 KB) - The end of the beginning?

Common sense signalling - ppE187 - E188

Richard K. Assoian

doi:10.1038/ncb0802-e187

Extracellular stimuli transmit information to cells by activating receptor-dependent signal-transduction cascades, most typically involving tyrosine and serine/threonine kinases. The cell's response to the activation of these kinases depends on the duration of their signals. New work now shows how cells sense the duration of an ERK signal in the G1 phase of the cell cycle. The study suggests that a common mechanism for sensing ERK signal duration may be involved in diverse cellular functions.

Full Text - Common sense signalling | PDF (100 KB) - Common sense signalling

GEF without a Dbl domain? - ppE188 - E190

Vania M. M. Braga

doi:10.1038/ncb0802-e188

Guanine nucleotide-exchange factors (GEFs) interact with and activate members of the Rho family of small GTPases through Dbl homology (DH) domains. A new domain has been found in DOCK180 and shown to specifically activate Rho proteins. Interestingly, this module does not contain any homology to Dbl sequences.

Full Text - GEF without a Dbl domain? | PDF (148 KB) - GEF without a Dbl domain?

Formins initiate new actin filaments - pE191

Thomas D. Pollard

doi:10.1038/ncb0802-e191a

Full Text - Formins initiate new actin filaments | PDF (100 KB) - Formins initiate new actin filaments

Chromosome instability: lessons from HIV - ppE191 - E193

Jan Paul Medema & René H. Medema

doi:10.1038/ncb0802-e191b

Modulating the cell cycle is essential for viral replication and infection. HIV is an expert at manipulating these processes. New work now shows how apoptosis of CD4/CXCR4-expressing T cells during the course of HIV-infection is intimately connected to aberrant cell-cycle regulation.

Full Text - Chromosome instability: lessons from HIV | PDF (262 KB) - Chromosome instability: lessons from HIV

'ER we go - pE193

Rachel Smallridge

doi:10.1038/ncb0802-e193

Full Text - 'ER we go | PDF (170 KB) - 'ER we go

Neuronal polarity: microtubules strike back - ppE194 - E195

Peter W. Baas

doi:10.1038/ncb0802-e194

Specification of one neurite as the axon is the first milestone achieved as neuronal polarity is established. It is clear that regional changes in the cytoskeleton underlie axonal differentiation, but is one cytoskeletal element any more crucial than the others? Although early studies implicated microtubules, more recent studies have focused on the actin cytoskeleton as the potential hub for factors that influence axonal differentiation. Now, studies on a novel protein called CRMP-2 have shifted attention back to microtubules.

Full Text - Neuronal polarity: microtubules strike back | PDF (176 KB) - Neuronal polarity: microtubules strike back

More than glue - pE196

Panos Z. Anastasiadis reviews Cell adhesion by Mary C. Beckerle

doi:10.1038/ncb0802-e196

Full Text - More than glue | PDF (137 KB) - More than glue

Heavy-strand Leitmotiv - pE197

Stephen Kearsey reviews Meselson, Stahl and the Replication of DNA by Frederic Lawrence Holmes

doi:10.1038/ncb0802-e197

Full Text - Heavy-strand Leitmotiv | PDF (108 KB) - Heavy-strand Leitmotiv

Cell cycling? Check your brakes - ppE199 - E201

Steven I. Reed

doi:10.1038/ncb0802-e199

First Paragraph - | Full Text - Cell cycling? Check your brakes | PDF (103 KB) - Cell cycling? Check your brakes

Kinase- and phosphatase-anchoring proteins: harnessing the dynamic duo - ppE203 - E206

Andrea L. Bauman & John D. Scott

doi:10.1038/ncb0802-e203

Abstract - | Full Text - Kinase- and phosphatase-anchoring proteins: harnessing the dynamic duo | PDF (368 KB) - Kinase- and phosphatase-anchoring proteins: harnessing the dynamic duo

-Arrestins regulate a Ral-GDS–Ral effector pathway that mediates cytoskeletal reorganization - pp547 - 555

Moshmi Bhattacharya, Pieter H. Anborgh, Andy V. Babwah, Lianne B. Dale, Tomas Dobransky, Jeffery L. Benovic, Ross D. Feldman, Joseph M. Verdi, R. Jane Rylett & Stephen S. G. Ferguson

doi:10.1038/ncb821

Abstract - | Full Text - -Arrestins regulate a Ral-GDS–Ral effector pathway that mediates cytoskeletal reorganization | PDF (825 KB) - -Arrestins regulate a Ral-GDS–Ral effector pathway that mediates cytoskeletal reorganization | Supplementary information

Molecular interpretation of ERK signal duration by immediate early gene products - pp556 - 564

Leon O. Murphy, Sallie Smith, Rey-Huei Chen, Diane C. Fingar & John Blenis

doi:10.1038/ncb822

Abstract - | Full Text - Molecular interpretation of ERK signal duration by immediate early gene products | PDF (2,086 KB) - Molecular interpretation of ERK signal duration by immediate early gene products | Supplementary information

EphrinA1-induced cytoskeletal re-organization requires FAK and p130^cas - pp565 - 573

Nigel Carter, Tetsuya Nakamoto, Hisamaru Hirai & Tony Hunter

doi:10.1038/ncb823

Abstract - | Full Text - EphrinA1-induced cytoskeletal re-organization requires FAK and p130cas | PDF (1,554 KB) - EphrinA1-induced cytoskeletal re-organization requires FAK and p130cas | Supplementary information

Unconventional Rac-GEF activity is mediated through the Dock180–ELMO complex - pp574 - 582

Enrico Brugnera, Lisa Haney, Cynthia Grimsley, Mingjian Lu, Scott F. Walk, Annie-Carole Tosello-Trampont, Ian G. Macara, Hiten Madhani, Gerald R. Fink & Kodimangalam S. Ravichandran

doi:10.1038/ncb824

Abstract - | Full Text - Unconventional Rac-GEF activity is mediated through the Dock180–ELMO complex | PDF (1,330 KB) - Unconventional Rac-GEF activity is mediated through the Dock180–ELMO complex | Supplementary information

CRMP-2 binds to tubulin heterodimers to promote microtubule assembly - pp583 - 591

Yuko Fukata, Tomohiko J. Itoh, Toshihide Kimura, Céline Ménager, Takashi Nishimura, Takashi Shiromizu, Hiroyasu Watanabe, Naoyuki Inagaki, Akihiro Iwamatsu, Hirokazu Hotani & Kozo Kaibuchi

doi:10.1038/ncb825

Abstract - | Full Text - CRMP-2 binds to tubulin heterodimers to promote microtubule assembly | PDF (768 KB) - CRMP-2 binds to tubulin heterodimers to promote microtubule assembly | Supplementary information

Kinesin I-dependent cortical exclusion restricts pole plasm to the oocyte posterior - pp592 - 598

Byeong-Jik Cha, Laura R. Serbus, Birgit S. Koppetsch & William E. Theurkauf

doi:10.1038/ncb832

Abstract - | Full Text - Kinesin I-dependent cortical exclusion restricts pole plasm to the oocyte posterior | PDF (1,959 KB) - Kinesin I-dependent cortical exclusion restricts pole plasm to the oocyte posterior

Connective-tissue growth factor (CTGF) modulates cell signalling by BMP and TGF- - pp599 - 604

José G. Abreu, Nan I. Ketpura, Bruno Reversade & E. M. De Robertis

doi:10.1038/ncb826

Abstract - | Full Text - Connective-tissue growth factor (CTGF) modulates cell signalling by BMP and TGF- | PDF (837 KB) - Connective-tissue growth factor (CTGF) modulates cell signalling by BMP and TGF- | Supplementary information

The epithelial-specific adaptor AP1B mediates post-endocytic recycling to the basolateral membrane - pp605 - 609

Yunbo Gan, Timothy E. McGraw & Enrique Rodriguez-Boulan

doi:10.1038/ncb827

Abstract - | Full Text - The epithelial-specific adaptor AP1B mediates post-endocytic recycling to the basolateral membrane | PDF (1,446 KB) - The epithelial-specific adaptor AP1B mediates post-endocytic recycling to the basolateral membrane | Supplementary information

Zebrafish trilobite identifies new roles for Strabismus in gastrulation and neuronal movements - pp610 - 615

Jason R. Jessen, Jacek Topczewski, Stephanie Bingham, Diane S. Sepich, Florence Marlow, Anand Chandrasekhar & Lilianna Solnica-Krezel

doi:10.1038/ncb828

Abstract - | Full Text - Zebrafish trilobite identifies new roles for Strabismus in gastrulation and neuronal movements | PDF (1,258 KB) - Zebrafish trilobite identifies new roles for Strabismus in gastrulation and neuronal movements | Supplementary information

Myosin VI is required for E-cadherin-mediated border cell migration - pp616 - 620

Erika R. Geisbrecht & Denise J. Montell

doi:10.1038/ncb830

Abstract - | Full Text - Myosin VI is required for E-cadherin-mediated border cell migration | PDF (856 KB) - Myosin VI is required for E-cadherin-mediated border cell migration

Tiam1 mediates Ras activation of Rac by a PI(3)K-independent mechanism - pp621 - 625

John M. Lambert, Que T. Lambert, Gary W. Reuther, Angeliki Malliri, David P. Siderovski, John Sondek, John G. Collard & Channing J. Der

doi:10.1038/ncb833

Abstract - | Full Text - Tiam1 mediates Ras activation of Rac by a PI(3)K-independent mechanism | PDF (310 KB) - Tiam1 mediates Ras activation of Rac by a PI(3)K-independent mechanism

An actin nucleation mechanism mediated by Bni1 and Profilin - pp626 - 631

Isabelle Sagot, Avital A. Rodal, James Moseley, Bruce L. Goode & David Pellman

doi:10.1038/ncb834

Abstract - | Full Text - An actin nucleation mechanism mediated by Bni1 and Profilin | PDF (732 KB) - An actin nucleation mechanism mediated by Bni1 and Profilin

Src-induced de-regulation of E-cadherin in colon cancer cells requires integrin signalling - pp632 - 638

Egle Avizienyte, Anne W. Wyke, Robert J. Jones, Gordon W. McLean, M. Andrew Westhoff, Valerie G. Brunton & Margaret C. Frame

doi:10.1038/ncb829

Abstract - | Full Text - Src-induced de-regulation of E-cadherin in colon cancer cells requires integrin signalling | PDF (2,852 KB) - Src-induced de-regulation of E-cadherin in colon cancer cells requires integrin signalling

Corrigendum: Leading the way - p638

doi:10.1038/ncb849

Full Text - Corrigendum: Leading the way | PDF (43 KB) - Corrigendum: Leading the way