Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Nitric oxide pumps up calcium signalling

Nature Cell Biology volume 1, pages E193–E195 (1999)Cite this article

Abstract

Nitric oxide released by vascular endothelial cells in the liver potentiates calcium signalling in surrounding hepatocytes. This may represent a mechanism by which endothelial cells of the microvasculature can play an active part in coordinating the cellular function of an organ.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Effects of nitric oxide (NO) on Ca2+ signalling.

References

  1. Berridge, M. J. Nature 386, 759–760 (1997).

    Article  CAS  Google Scholar 

  2. Patel, S., Robb-Gaspers, L. D., Stellato, K. A., Shon, M. & Thomas, A. P. Nature Cell Biol. 1, 467–471 (1999).

    Article  CAS  Google Scholar 

  3. Guthrie, P. B. et al. J. Neurosci. 19, 520–528 (1999).

    Article  CAS  Google Scholar 

  4. Boitano, S., Dirksen, E. R. & Sanderson, M. J. Science 258, 292–295 (1992).

    Article  CAS  Google Scholar 

  5. Ignarro, L. J. FASEB J. 3, 31–36 (1989).

    Article  CAS  Google Scholar 

  6. Komalavilas, P. & Lincoln, T. M. J. Biol. Chem. 269, 8701–8707 (1994).

    CAS  PubMed  Google Scholar 

  7. Kasai, Y., Yamazawa, T., Sakurai, T., Taketani, Y. & Iino, M. J. Physiol. (Lond.) 504, 349–357 (1997).

    Article  CAS  Google Scholar 

  8. Rooney, T. A., Joseph, S. K., Queen, C. & Thomas, A. P. J. Biol. Chem. 271, 19817–19825 (1996).

    Article  CAS  Google Scholar 

  9. Guihard, G., Combettes, L. & Capiod, T. Biochem. J. 318, 849–855 (1996).

    Article  CAS  Google Scholar 

  10. Moncada, S. Ann. NY Acad. Sci. 811, 60–67 (1997).

    Article  CAS  Google Scholar 

  11. Young, R. C. & Hession, R. O. Obstet. Gynecol. 90, 928–932 (1997).

    Article  CAS  Google Scholar 

  12. Charles, A. Glia 24, 39–49 (1998).

    Article  CAS  Google Scholar 

  13. Araque, A., Parpura, V., Sanzgiri, R. P. & Haydon, P. G. Trends Neurosci. 22, 208–215 (1999).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. the UCLA Department of Neurology, 710 Westwood Plaza, Los Angeles, 90095, California, USA

    Andrew Charles

Authors
  1. Andrew Charles
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Andrew Charles.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Charles, A. Nitric oxide pumps up calcium signalling. Nat Cell Biol 1, E193–E195 (1999). https://doi.org/10.1038/70221

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/70221

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing