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Perez and Lehner summarize recent discoveries regarding epigenetic inheritance across generations and review the molecular mechanisms underlying non-DNA sequence-based transmissions.
This Review describes non-redundant functions of the core transcription factors that mediate the epithelial–mesenchymal transition, and discusses the conflicting results regarding their roles in this process.
Moreno-Layseca et al. discuss how integrins, key receptors that mediate cell adhesion to the extracellular matrix, are endocytosed and recycled to the cell surface to modulate cell and tissue behaviour.
In this Review Article, Chunduri and Storchová discuss how aneuploidy, often seen in cancer cells, affects gene expression, proliferation, proteotoxic stress and genomic stability, and how these changes relate to those in cancer.
In this Perspective, Théry and co-authors discuss our current understanding of the biogenesis, secretion and uptake of exosomes and extracellular vesicles.
Valencia and Kadoch review diverse functions of DNA and histone modifying proteins, and chromatin remodelling complexes in cancer, and discuss how these may be favourably leveraged for therapeutic development.
Jacobsen and Nerlov discuss the complexity, benefits and intrinsic limitations of studying haematopoiesis at the single-cell level using established and emerging technologies.
In this Perspective, Fässler and co-authors describe current models of how integrin adhesion molecules are activated and stabilised, and the importance of forces in this process.
Joungmok Kim and Kunliang Guan review the landmark discoveries in the mTOR field from the identification of rapamycin to the characterization of mTOR complex components, with an emphasis on the key players mediating amino acid signals to mTOR.
Lee and Schmitt discuss how the classical view of senescence as a static, terminally differentiated state has changed to that of a dynamic, reversible condition with diverse roles in tumour biology.
In this Review, Horng and colleagues cover the emerging roles of cellular metabolism in guiding immune cell activation and cell fate decisions, and discuss how differential metabolic regulation allows for context specificity.
In this Perspective, Dekoninck and Blanpain describe the characteristics of skin epithelial stem cells, their heterogeneity, clonal dynamics, crosstalk with other cells and remarkable plasticity during wound healing.
In this Review, Lawrence and Zoncu discuss the central role of the lysosome in cellular metabolism, including in macromolecular catabolism and nutrient recycling, and organelle crosstalk. They highlight the emerging function of the lysosome as a centre for nutrient sensing and metabolic signal transduction.
In this Review, Schermelleh et al. give an overview of current super-resolution microscopy techniques and provide guidance on how best to use them to foster biological discovery.
Brunet and colleagues review emerging rejuvenation strategies that could counteract ageing features, and discuss their mechanisms of action and application against human ageing.
